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    myo1b myosin IB [ Danio rerio (zebrafish) ]

    Gene ID: 541515, updated on 9-Dec-2024

    Summary

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    Official Symbol
    myo1bprovided by ZNC
    Official Full Name
    myosin IBprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-695
    See related
    Ensembl:ENSDARG00000024694 AllianceGenome:ZFIN:ZDB-GENE-030131-695
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    myo1b2; myo1bl1; myo1bl2; wu:fb39h10; wu:fc46c09; zgc:110446; zgc:113187; DKEY-242N5.2; si:busm1-60j23.1
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization; actin filament-based movement; and endocytosis. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; brush border; and microvillus. Is expressed in dorsolateral placode; lens; notochord; rhombomere; and somite. Orthologous to human MYO1B (myosin IB). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See myo1b in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (16127194..16239035, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (16189192..16301790, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene cytokine receptor family member b4 Neighboring gene uridine phosphorylase 2 Neighboring gene si:ch211-261p9.4 Neighboring gene uncharacterized LOC137496422

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Myosin-1 inhibition by PClP affects membrane shape, cortical actin distribution and lipid droplet dynamics in early Zebrafish embryos. Gupta P, et al. PLoS One, 2017. PMID 28678859, Free PMC Article
    2. Non-muscle myosin IIA and IIB differentially regulate cell shape changes during zebrafish brain morphogenesis. Gutzman JH, et al. Dev Biol, 2015 Jan 1. PMID 25446029
    3. Control of directed cell migration in vivo by membrane-to-cortex attachment. Diz-Muñoz A, et al. PLoS Biol, 2010 Nov 30. PMID 21151339, Free PMC Article
    4. Expression of unconventional myosin genes during neuronal development in zebrafish. Sittaramane V, et al. Gene Expr Patterns, 2008 Feb. PMID 18078791, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate a potential role for Myo1 in the maintenance and formation of furrow, blastodisc morphology, cell-division and lipid droplets (LDs) organization within the blastodisc during early embryogenesis.
      Title: Myosin-1 inhibition by PClP affects membrane shape, cortical actin distribution and lipid droplet dynamics in early Zebrafish embryos.
    2. NMIIA and NMIIB perform distinct functions in regulating cell shape during MHB morphogenesis
      Title: Non-muscle myosin IIA and IIB differentially regulate cell shape changes during zebrafish brain morphogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110446

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin-Ib; unconventional myosin-Ib
    Names
    myosin 1b-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      16127194..16239035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001920924.8 → XP_001920959.3  unconventional myosin-Ib isoform X6

      UniProtKB/TrEMBL
      A0A8M1QLB6, A0A8M2BFG0
      Conserved Domains (3) summary
      smart00242
      Location:13 → 698
      MYSc; Myosin. Large ATPases
      cd01378
      Location:26 → 685
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:880 → 1053
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    2. XM_005167951.5 → XP_005168008.1  unconventional myosin-Ib isoform X5

      UniProtKB/TrEMBL
      A0A8M2BFD8, A0A8M2BFE9, F1R617
      Related
      ENSDARP00000121299.3, ENSDART00000138204.4
      Conserved Domains (3) summary
      smart00242
      Location:13 → 698
      MYSc; Myosin. Large ATPases
      cd01378
      Location:26 → 685
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:909 → 1082
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    3. XM_068223572.1 → XP_068079673.1  unconventional myosin-Ib isoform X4

      UniProtKB/TrEMBL
      A0A8M2BFF2

    4. XM_009304573.4 → XP_009302848.1  unconventional myosin-Ib isoform X2

      UniProtKB/TrEMBL
      A0A8M3AVX4, A0A8M3B5I5
      Conserved Domains (3) summary
      smart00242
      Location:13 → 698
      MYSc; Myosin. Large ATPases
      cd01378
      Location:26 → 685
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:938 → 1111
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    5. XM_068223571.1 → XP_068079672.1  unconventional myosin-Ib isoform X3

      UniProtKB/TrEMBL
      A0A8M3B2K3

    6. XM_003199193.6 → XP_003199241.2  unconventional myosin-Ib isoform X1

      UniProtKB/TrEMBL
      A0A8M1RIU5, A0A8M2BG11
      Conserved Domains (3) summary
      smart00242
      Location:13 → 698
      MYSc; Myosin. Large ATPases
      cd01378
      Location:26 → 685
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:967 → 1140
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001014328.1: Suppressed sequence

      Description
      NM_001014328.1: This RefSeq was temporarily suppressed because the source sequence appears to encode only a fragment of a myosin family member.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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