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    cops2 COP9 signalosome subunit 2 [ Danio rerio (zebrafish) ]

    Gene ID: 415145, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cops2provided by ZNC
    Official Full Name
    COP9 signalosome subunit 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040625-15
    See related
    Ensembl:ENSDARG00000004785 AllianceGenome:ZFIN:ZDB-GENE-040625-15
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:86624; wu:fc05f05; wu:fc06g10; wu:fc60f04; wu:fl94f12
    Summary
    Predicted to be involved in negative regulation of transcription by RNA polymerase II and protein deneddylation. Predicted to be located in nucleus. Predicted to be part of COP9 signalosome. Orthologous to human COPS2 (COP9 signalosome subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cops2 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (32366064..32381629, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (31955102..31970706, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 27 member 2b Neighboring gene centrosomal protein 152 Neighboring gene uncharacterized LOC103909877 Neighboring gene uncharacterized LOC101882990

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Modulation of Zebrafish (Danio rerio) Intestinal Mucosal Barrier Function Fed Different Postbiotics and a Probiotic from Lactobacilli. Rawling M, et al. Microorganisms, 2023 Nov 30. PMID 38138044, Free PMC Article
    2. Deletion of a conserved Gata2 enhancer impairs haemogenic endothelium programming and adult Zebrafish haematopoiesis. Dobrzycki T, et al. Commun Biol, 2020 Feb 13. PMID 32054973, Free PMC Article
    3. Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression. Bertrand S, et al. PLoS Genet, 2007 Nov. PMID 17997606, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein deneddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome complex subunit 2
    Names
    Alien
    COP9 constitutive photomorphogenic homolog subunit 2
    signalosome subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002055.1 → NP_001002055.1  COP9 signalosome complex subunit 2

      See identical proteins and their annotated locations for NP_001002055.1

      Status: PROVISIONAL

      Source sequence(s)
      BC071320
      UniProtKB/Swiss-Prot
      Q6IQT4
      Related
      ENSDARP00000012359.5, ENSDART00000006124.8
      Conserved Domains (2) summary
      COG5159
      Location:40 → 441
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:309 → 413
      PCI; PCI domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      32366064..32381629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470471.2 → XP_021326146.1  COP9 signalosome complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PUW2
      Conserved Domains (2) summary
      COG5159
      Location:164 → 411
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:279 → 383
      PCI; PCI domain

    2. XM_005163159.5 → XP_005163216.1  COP9 signalosome complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BAA6
      Conserved Domains (3) summary
      COG5159
      Location:40 → 443
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:311 → 415
      PCI; PCI domain
      pfam12018
      Location:86 → 220
      DUF3508; Domain of unknown function (DUF3508)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IQT4.1 GenPept UniProtKB/Swiss-Prot:Q6IQT4

    Gene LinkOut

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