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    cpt1ab carnitine palmitoyltransferase 1Ab (liver) [ Danio rerio (zebrafish) ]

    Gene ID: 560000, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpt1abprovided by ZNC
    Official Full Name
    carnitine palmitoyltransferase 1Ab (liver)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3250
    See related
    Ensembl:ENSDARG00000062054 AllianceGenome:ZFIN:ZDB-GENE-030131-3250
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc31g06; wu:fc31g06; si:ch211-236l14.3
    Summary
    Predicted to enable carnitine O-palmitoyltransferase activity. Acts upstream of or within regulation of fatty acid beta-oxidation. Predicted to be located in membrane. Predicted to be active in mitochondrion. Is expressed in cardiac ventricle and liver. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency and lipid metabolism disorder. Orthologous to human CPT1A (carnitine palmitoyltransferase 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cpt1ab in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (23592068..23643257)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (23494485..23546636)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology-like domain, family A, member 2 Neighboring gene nucleosome assembly protein 1-like 4a Neighboring gene si:ch211-236l14.4 Neighboring gene si:ch211-236l14.1 Neighboring gene uncharacterized LOC137489358

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Live imaging reveals a conserved role of fatty acid β-oxidation in early lymphatic development in zebrafish. Zecchin A, et al. Biochem Biophys Res Commun, 2018 Sep 3. PMID 29730294
    2. Identification and Characterization of Carnitine Palmitoyltransferase 1 (cpt 1) Genes in Nile Tilapia, Oreochromis niloticus. Bayır M, et al. Evol Bioinform Online, 2020. PMID 32231427, Free PMC Article
    3. Bacillus licheniformis FA6 Affects Zebrafish Lipid Metabolism through Promoting Acetyl-CoA Synthesis and Inhibiting β-Oxidation. Chen S, et al. Int J Mol Sci, 2022 Dec 30. PMID 36614116, Free PMC Article
    4. Perfluorooctane sulfonate promotes doxycycline-induced liver tumor progression in male Kras(v12) transgenic zebrafish. Zhu Y, et al. Environ Res, 2021 May. PMID 33675800
    5. Nonalcoholic Fatty Liver Disease Development in Zebrafish upon Exposure to Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate, a Novel Brominated Flame Retardant. Guo W, et al. Environ Sci Technol, 2021 May 18. PMID 33938212

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine O-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carnitine O-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carnitine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of lymph vessel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carnitine O-palmitoyltransferase 1, liver isoform

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      23592068..23643257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170707.5 → XP_005170764.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X1

      UniProtKB/TrEMBL
      A0A8M2BIG5, E9QI17
      Related
      ENSDARP00000083632.5, ENSDART00000089199.6
      Conserved Domains (2) summary
      pfam00755
      Location:172 → 762
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:1 → 46
      CPT_N; Carnitine O-palmitoyltransferase N-terminus

    2. XM_002666847.7 → XP_002666893.2  carnitine O-palmitoyltransferase 1, liver isoform isoform X2

      UniProtKB/TrEMBL
      A0A8M1REG9, K7DY29
      Related
      ENSDARP00000126355.1, ENSDART00000151938.3
      Conserved Domains (2) summary
      pfam00755
      Location:172 → 761
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:1 → 46
      CPT_N; Carnitine O-palmitoyltransferase N-terminus

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395205.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      115845..162010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473872.2 → XP_021329547.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X1

      UniProtKB/TrEMBL
      A0A8M9PEG9
      Conserved Domains (2) summary
      pfam00755
      Location:172 → 759
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:1 → 46
      CPT_N; Carnitine O-palmitoyltransferase N-terminus

    2. XM_021473873.2 → XP_021329548.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X2

      UniProtKB/TrEMBL
      A0A8M9PR97
      Conserved Domains (2) summary
      pfam00755
      Location:172 → 758
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:1 → 46
      CPT_N; Carnitine O-palmitoyltransferase N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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