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    sin3ab SIN3 transcription regulator family member Ab [ Danio rerio (zebrafish) ]

    Gene ID: 323346, updated on 4-Jan-2025

    Summary

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    Official Symbol
    sin3abprovided by ZNC
    Official Full Name
    SIN3 transcription regulator family member Abprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2066
    See related
    Ensembl:ENSDARG00000059812 AllianceGenome:ZFIN:ZDB-GENE-030131-2066
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb95g11; wu:fb95g11
    Summary
    Predicted to enable transcription corepressor activity. Acts upstream of or within heart development. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See sin3ab in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (48347290..48396207, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (48074498..48123465, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 44b Neighboring gene cellular retinoic acid binding protein 1b Neighboring gene leucine rich repeat and Ig domain containing 1b Neighboring gene potassium voltage-gated channel, KQT-like subfamily, member 1.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish sin3b mutants are viable but have size, skeletal, and locomotor defects. Moravec CE, et al. Dev Dyn, 2017 Nov. PMID 28850761, Free PMC Article
    2. Sin3a associated protein 130 kDa, sap130, plays an evolutionary conserved role in zebrafish heart development. DeMoya RA, et al. Front Cell Dev Biol, 2023. PMID 37711853, Free PMC Article
    3. Zebrafish rest regulates developmental gene expression but not neurogenesis. Kok FO, et al. Development, 2012 Oct. PMID 22951640, Free PMC Article
    4. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SIN3 transcription regulator family member Ab; paired amphipathic helix protein Sin3a
    Names
    SIN3 homolog A, transcription regulator b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      48347290..48396207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002662877.7 → XP_002662923.1  paired amphipathic helix protein Sin3a isoform X2

      UniProtKB/TrEMBL
      A0A8M1RR38, E7F0R9
      Related
      ENSDARP00000077990.5, ENSDART00000083555.7
      Conserved Domains (4) summary
      COG5602
      Location:110 → 1211
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:136 → 180
      PAH; Paired amphipathic helix repeat
      pfam08295
      Location:548 → 642
      Sin3_corepress; Sin3 family co-repressor
      pfam16879
      Location:880 → 1178
      Sin3a_C; C-terminal domain of Sin3a protein

    2. XM_009303423.4 → XP_009301698.1  paired amphipathic helix protein Sin3a isoform X1

      UniProtKB/TrEMBL
      A0A8M3B4C3
      Conserved Domains (4) summary
      COG5602
      Location:110 → 1218
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:136 → 180
      PAH; Paired amphipathic helix repeat
      pfam08295
      Location:555 → 649
      Sin3_corepress; Sin3 family co-repressor
      pfam16879
      Location:887 → 1185
      Sin3a_C; C-terminal domain of Sin3a protein
    Nucleotide Protein Strain
    Heading Accession and Version

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