kifbp kinesin family binding protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kifbpprovided by ZNC
Official Full Name: kinesin family binding proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070117-1989
See related: Ensembl:ENSDARG00000062053 AllianceGenome:ZFIN:ZDB-GENE-070117-1989
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: kbp; kif1bp; unst23; fc59b03; kiaa1279; wu:fc59b03; zgc:112085
Summary: Acts upstream of or within enteric nervous system development; microtubule cytoskeleton organization; and plasma membrane bounded cell projection organization. Predicted to be located in mitochondrion. Is expressed in gut and nervous system. Used to study Goldberg-Shprintzen syndrome. Human ortholog(s) of this gene implicated in Goldberg-Shprintzen syndrome. Orthologous to human KIFBP (kinesin family binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (23083856..23095010, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (22953406..22964560, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish studies further demonstrated an epistatic interaction between KBP and SCG10 in vivo.
Title: KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation.
kbp is required for axonal outgrowth and maintenance.
Title: KBP is essential for axonal structure, outgrowth and maintenance in zebrafish, providing insight into the cellular basis of Goldberg-Shprintzen syndrome.

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General gene information

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Markers

fk83a08.x1 (e-PCR)
- UniSTS:201590

fb53c01.y1 (e-PCR)
- UniSTS:190675

fc59b03 (e-PCR), detects polymorphism
- UniSTS:189439

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in central nervous system projection neuron axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system projection neuron axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within efferent axon development in posterior lateral line nerve	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within enteric nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion transport along microtubule	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron projection maintenance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron projection maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: KIF-binding protein

Names: KIF1-binding protein homolog; kif1 binding protein; unm st23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013462.3 → NP_001013480.3 KIF-binding protein

Status: PROVISIONAL

Source sequence(s)

BX546482

UniProtKB/Swiss-Prot

A8WE67

UniProtKB/TrEMBL

A0A8M1N4F8, B8A5I1

Related

ENSDARP00000083675.4, ENSDART00000089242.5

Conserved Domains (1) summary

pfam12309
Location:254 → 623

KBP_C; KIF-1 binding protein C terminal