U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cldn12 claudin 12 [ Danio rerio (zebrafish) ]

    Gene ID: 81593, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cldn12provided by ZNC
    Official Full Name
    claudin 12provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010328-14
    See related
    Ensembl:ENSDARG00000003927 AllianceGenome:ZFIN:ZDB-GENE-010328-14
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:86588; wu:fc27c11; wu:fc37h01
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including eye; gill; gut; heart; and pleuroperitoneal region. Orthologous to human CLDN12 (claudin 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cldn12 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (43227724..43233509, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (43323966..43329751, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 40 Neighboring gene DBF4-CDC7 kinase regulatory subunit Neighboring gene ADAM metallopeptidase domain 22 Neighboring gene WASH complex subunit 5 Neighboring gene proteasome 20S subunit alpha 2a Neighboring gene mitochondrial ribosomal protein L32

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Dietary nucleotides can directly stimulate the immunity of zebrafish independent of the intestinal microbiota. Guo X, et al. Fish Shellfish Immunol, 2019 Mar. PMID 30590163
    2. Exogenous GDF9 but not Activin A, BMP15 or TGFβ alters tight junction protein transcript abundance in zebrafish ovarian follicles. Clelland ES, et al. Gen Comp Endocrinol, 2011 Apr 1. PMID 21291886
    3. Strategies for maintaining Na⁺ balance in zebrafish (Danio rerio) during prolonged exposure to acidic water. Kumai Y, et al. Comp Biochem Physiol A Mol Integr Physiol, 2011 Sep. PMID 21600298
    4. Surface-Displayed Amuc_1100 From Akkermansia muciniphila on Lactococcus lactis ZHY1 Improves Hepatic Steatosis and Intestinal Health in High-Fat-Fed Zebrafish. Zhang FL, et al. Front Nutr, 2021. PMID 34722607, Free PMC Article
    5. Tight junction proteins in zebrafish ovarian follicles: stage specific mRNA abundance and response to 17beta-estradiol, human chorionic gonadotropin, and maturation inducing hormone. Clelland ES, et al. Gen Comp Endocrinol, 2010 Sep 15. PMID 20553723

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    claudin-12

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131773.2 → NP_571848.1  claudin-12

      See identical proteins and their annotated locations for NP_571848.1

      Status: VALIDATED

      Source sequence(s)
      CR848685, EH545623
      UniProtKB/TrEMBL
      A0A8M1PC43, Q90XR1
      Related
      ENSDARP00000014514.6, ENSDART00000025877.8
      Conserved Domains (1) summary
      pfam03153
      Location:204 → 317
      TFIIA; Transcription factor IIA, alpha/beta subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      43227724..43233509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools