lsg1 large 60S subunit nuclear export GTPase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lsg1provided by ZNC
Official Full Name: large 60S subunit nuclear export GTPase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2184
See related: Ensembl:ENSDARG00000015352 AllianceGenome:ZFIN:ZDB-GENE-030131-2184
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb99b06; zgc:76988; wu:fb99b06
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in ribosomal subunit export from nucleus. Predicted to act upstream of or within protein transport. Predicted to be located in Cajal body and endoplasmic reticulum. Predicted to be active in cytosol. Is expressed in eye; immature eye; midbrain; neural plate; and segmental plate. Orthologous to human LSG1 (large 60S subunit nuclear export GTPase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (34219997..34232673, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (33957565..33970241, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nuclear export	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in ribosomal subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Cajal body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: large subunit GTPase 1 homolog

NP_997807.1

EC 3.6.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212642.1 → NP_997807.1 large subunit GTPase 1 homolog

See identical proteins and their annotated locations for NP_997807.1

Status: PROVISIONAL

Source sequence(s)

BC066695

UniProtKB/Swiss-Prot

Q6NY89

Related

ENSDARP00000134827.1, ENSDART00000162150.2

Conserved Domains (2) summary

cd01857
Location:164 → 426

HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases

COG1161
Location:152 → 534

RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]