pwp2h PWP2 small subunit processome component [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pwp2hprovided by ZNC
Official Full Name: PWP2 small subunit processome componentprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021031-3
See related: Ensembl:ENSDARG00000037109 AllianceGenome:ZFIN:ZDB-GENE-021031-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb471; zgc:56063
Summary: Acts upstream of or within digestive system development and ribosomal small subunit assembly. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Is expressed in several structures, including brain; digestive system; head; immature eye; and mesoderm. Orthologous to human PWP2 (PWP2 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (28899449..28950366, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (28095617..28146534, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

pwp2h-deficient model, titania (ttis450), the growth of the endodermal organs, eyes, brain and craniofacial structures is severely arrested and autophagy is markedly up-regulated
Title: Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis.
At the subcellular level, Pwp2h protein appears to be localized to the region of the nucleolus consistent with its presumed function in ribosomal RNA synthesis.
Title: Live imaging of endogenous periodic tryptophan protein 2 gene homologue during zebrafish development.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within digestive system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ribosomal small subunit assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ribosome biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Pwp2p-containing subcomplex of 90S preribosome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PWP2 small subunit processome component

Names: PWP2 periodic tryptophan protein homolog; titania; tti

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213047.1 → NP_998212.1 PWP2 small subunit processome component

See identical proteins and their annotated locations for NP_998212.1

Status: PROVISIONAL

Source sequence(s)

BC047817

UniProtKB/TrEMBL

Q7ZUV4

Related

ENSDARP00000101591.2, ENSDART00000110270.4

Conserved Domains (5) summary

COG2319
Location:1 → 460

WD40; WD40 repeat [General function prediction only]

cd00200
Location:334 → 645

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam04003
Location:786 → 884

Utp12; Dip2/Utp12 Family

sd00039
Location:345 → 383

7WD40; WD40 repeat [structural motif]

cl02567
Location:55 → 413

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...