ssh2a slingshot protein phosphatase 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ssh2aprovided by ZNC
Official Full Name: slingshot protein phosphatase 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3810
See related: Ensembl:ENSDARG00000088440 AllianceGenome:ZFIN:ZDB-GENE-030131-3810
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ssh2; wu:fc54g05
Summary: Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Predicted to be involved in actin cytoskeleton organization and negative regulation of actin filament polymerization. Predicted to act upstream of or within protein dephosphorylation. Predicted to be active in cytoplasm. Orthologous to human SSH2 (slingshot protein phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (28548628..28587044, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (28615752..28654281, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc59d06.y1 (e-PCR)
- UniSTS:194140

fc54g05 (e-PCR)
- UniSTS:189344

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein dephosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein phosphatase Slingshot homolog 2

Names: slingshot homolog 2; slingshot homolog 2a

XP_001921323.1

EC 3.1.3.16

XP_005157728.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

28548628..28587044 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001921288.8 → XP_001921323.1 protein phosphatase Slingshot homolog 2 isoform X2

UniProtKB/TrEMBL

A0A8M1QV03, X1WFY2

Related

ENSDARP00000129137.1, ENSDART00000156049.2

Conserved Domains (3) summary

cd11652
Location:3 → 238

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

cd00127
Location:310 → 445

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

pfam08766
Location:253 → 304

DEK_C; DEK C terminal domain
XM_005157671.5 → XP_005157728.1 protein phosphatase Slingshot homolog 2 isoform X1

UniProtKB/TrEMBL

A0A8M2B4L4, E7FH10

Related

ENSDARP00000112052.1, ENSDART00000127845.3

Conserved Domains (3) summary

cd11652
Location:12 → 245

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

cd00127
Location:317 → 452

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

pfam08766
Location:260 → 311

DEK_C; DEK C terminal domain