opa1 OPA1 mitochondrial dynamin like GTPase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: opa1provided by ZNC
Official Full Name: OPA1 mitochondrial dynamin like GTPaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041114-7
See related: Ensembl:ENSDARG00000070801 AllianceGenome:ZFIN:ZDB-GENE-041114-7
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fk62d06; zgc:92092; wu:fb77a10; wu:fk62d06
Summary: Predicted to enable several functions, including GTPase-dependent fusogenic activity; membrane bending activity; and phospholipid binding activity. Acts upstream of or within chordate embryonic development; mitochondrion organization; and ventricular cardiac muscle cell development. Predicted to be located in mitochondrial inner membrane. Predicted to be active in microtubule; mitochondrial intermembrane space; and mitochondrial membrane. Is expressed in brain; eye; retina; retinal photoreceptor layer; and retinal pigmented epithelium. Human ortholog(s) of this gene implicated in Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; optic atrophy; and optic atrophy 1. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (36720153..36795162, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (36742263..36817289, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

To our knowledge, our study is the first composite analysis of sirtuins in adult zebrafish retina and provides sufficient evidence that resveratrol, as an activator of SIRT1, protects NMDA-induced zebrafish retinal damage by potentially mediating mitochondrial sirtuins and OPA1 genes.
Title: Effect of Resveratrol on Sirtuins, OPA1, and Fis1 Expression in Adult Zebrafish Retina.
Opa1 is required for proper mitochondrial metabolism in early development
Title: Opa1 is required for proper mitochondrial metabolism in early development.

Submit: New GeneRIF Correction

General gene information

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Markers

fk62d06.x1 (e-PCR)
- UniSTS:201317

fb77a10.x1 (e-PCR)
- UniSTS:191334

fb77a10.x1 (e-PCR)
- UniSTS:191335

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase-dependent fusogenic activity	ISS Inferred from Sequence or Structural Similarity more info
enables cardiolipin binding	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables membrane bending activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidic acid binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in GTP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular distribution of mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane tubulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial inner membrane fusion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T-helper 17 cell lineage commitment	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-17 production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ventricular cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynamin-like GTPase OPA1, mitochondrial

Names: dynamin-like 120 kDa protein, mitochondrial; optic atrophy 1 (autosomal dominant)

NP_001007299.1

EC 3.6.5.5

XP_009300789.1

EC 3.6.5.5

XP_017211966.2

EC 3.6.5.5

XP_021332522.1

EC 3.6.5.5

XP_021332523.1

EC 3.6.5.5

XP_021332524.1

EC 3.6.5.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007298.1 → NP_001007299.1 dynamin-like GTPase OPA1, mitochondrial precursor

See identical proteins and their annotated locations for NP_001007299.1

Status: PROVISIONAL

Source sequence(s)

BC085633

UniProtKB/Swiss-Prot

Q5U3A7

UniProtKB/TrEMBL

A0A8M9QFC7

Related

ENSDARP00000095031.2, ENSDART00000104256.4

Conserved Domains (2) summary

cd08771
Location:293 → 567

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

cl10013
Location:841 → 958

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

36720153..36795162 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021476848.2 → XP_021332523.1 dynamin-like GTPase OPA1, mitochondrial isoform X4

UniProtKB/TrEMBL

A0A8M9PZN8, A0A8M9QFC7

Conserved Domains (1) summary

cd08771
Location:344 → 618

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
XM_021476847.2 → XP_021332522.1 dynamin-like GTPase OPA1, mitochondrial isoform X3

UniProtKB/TrEMBL

A0A8M9PM18, A0A8M9QFC7

Related

ENSDARP00000145882.1, ENSDART00000187751.1

Conserved Domains (1) summary

cd08771
Location:345 → 619

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
XM_021476849.2 → XP_021332524.1 dynamin-like GTPase OPA1, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8M9Q626, A0A8M9QFC7

Conserved Domains (1) summary

cd08771
Location:309 → 583

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
XM_017356477.3 → XP_017211966.2 dynamin-like GTPase OPA1, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A8M6Z7B4, A0A8M9QFC7

Conserved Domains (1) summary

cd08771
Location:360 → 634

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
XM_009302514.4 → XP_009300789.1 dynamin-like GTPase OPA1, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A0R4IJ30, A0A8M9QFC3, A0A8M9QFC7

Related

ENSDARP00000133518.1, ENSDART00000161928.2

Conserved Domains (1) summary

cd08771
Location:361 → 635

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins