sestd1 SEC14 and spectrin domains 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sestd1provided by ZNC
Official Full Name: SEC14 and spectrin domains 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030801-1
See related: Ensembl:ENSDARG00000040614 AllianceGenome:ZFIN:ZDB-GENE-030801-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: duo; sol; HAPIP; cb248; sb:cb248; dZ106A20.1; si:dz42h5.2; si:dz106a20.1; si:dz106a20.2
Summary: Predicted to enable phosphatidylinositol phosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Acts upstream of or within blood vessel morphogenesis. Is expressed in axial chorda mesoderm; myotome; notochord; retinal inner nuclear layer; and somite. Orthologous to human SESTD1 (SEC14 and spectrin domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (43149854..43213231, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (43348066..43411450, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fd06a06.x1 (e-PCR)
- UniSTS:194977

fi22h04.y1 (e-PCR)
- UniSTS:197055

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphatidylinositol-3,4-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-5-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: SEC14 domain and spectrin repeat-containing protein 1

Names: huntingtin-associated; protein Solo; solo

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182881.2 → NP_878301.2 SEC14 domain and spectrin repeat-containing protein 1

See identical proteins and their annotated locations for NP_878301.2

Status: PROVISIONAL

Source sequence(s)

BC134893

UniProtKB/Swiss-Prot

A4IG23, Q7SX85, Q7ZZ43, Q8AW09

Related

ENSDARP00000059447.4, ENSDART00000059448.6

Conserved Domains (2) summary

pfam13716
Location:28 → 147

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02488
Location:383 → 607

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

43149854..43213231 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005167875.5 → XP_005167932.1 SEC14 domain and spectrin repeat-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_005167932.1

UniProtKB/Swiss-Prot

A4IG23, Q7SX85, Q7ZZ43, Q8AW09

Related

ENSDARP00000116017.1, ENSDART00000139775.3

Conserved Domains (2) summary

pfam13716
Location:28 → 147

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02488
Location:383 → 607

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...