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    vill villin-like [ Danio rerio (zebrafish) ]

    Gene ID: 555361, updated on 9-Dec-2024

    Summary

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    Official Symbol
    villprovided by ZNC
    Official Full Name
    villin-likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081222-1
    See related
    Ensembl:ENSDARG00000001909 AllianceGenome:ZFIN:ZDB-GENE-081222-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable actin filament binding activity. Predicted to act upstream of or within actin filament capping and cytoskeleton organization. Orthologous to human VILL (villin like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See vill in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (20418226..20449959, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (20274282..20305540, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene acetyl-CoA acyltransferase 1 Neighboring gene DLEC1 cilia and flagella associated protein Neighboring gene phospholipase C, delta 1a Neighboring gene uncharacterized LOC137489234 Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like a Neighboring gene microRNA 26a-3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection. Delgadillo-Silva LF, et al. Dis Model Mech, 2019 Jan 23. PMID 30679186, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    villin-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      20418226..20449959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009297407.4 → XP_009295682.1  villin-like protein isoform X4

      See identical proteins and their annotated locations for XP_009295682.1

      UniProtKB/TrEMBL
      A0A8M3AP84, E7FC92
      Conserved Domains (7) summary
      cd11288
      Location:511 → 601
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:134 → 222
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8 → 118
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:616 → 713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:249 → 346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:390 → 490
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:816 → 850
      VHP; Villin headpiece domain

    2. XM_021470314.2 → XP_021325989.1  villin-like protein isoform X3

      UniProtKB/TrEMBL
      A0A8M9PM91
      Conserved Domains (7) summary
      cd11288
      Location:571 → 661
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:194 → 282
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:68 → 178
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:676 → 773
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:309 → 406
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:450 → 550
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:856 → 890
      VHP; Villin headpiece domain

    3. XM_021470312.2 → XP_021325987.1  villin-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8M9P642
      Conserved Domains (7) summary
      cd11288
      Location:571 → 661
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:194 → 282
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:68 → 178
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:676 → 773
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:309 → 406
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:450 → 550
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:876 → 910
      VHP; Villin headpiece domain

    4. XM_021470313.2 → XP_021325988.1  villin-like protein isoform X2

      UniProtKB/TrEMBL
      A0A8M9PGD1
      Conserved Domains (7) summary
      cd11288
      Location:564 → 654
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:187 → 275
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:61 → 171
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:669 → 766
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:302 → 399
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:443 → 543
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:869 → 903
      VHP; Villin headpiece domain

    5. XM_068217194.1 → XP_068073295.1  villin-like protein isoform X4

      UniProtKB/TrEMBL
      A0A8M3AP84, E7FC92
      Related
      ENSDARP00000048939.5, ENSDART00000048940.7
    Nucleotide Protein Strain
    Heading Accession and Version

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