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    mdh2 malate dehydrogenase 2, NAD (mitochondrial) [ Danio rerio (zebrafish) ]

    Gene ID: 406405, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mdh2provided by ZNC
    Official Full Name
    malate dehydrogenase 2, NAD (mitochondrial)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2143
    See related
    Ensembl:ENSDARG00000043371 AllianceGenome:ZFIN:ZDB-GENE-040426-2143
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:64133; wu:fj48c08; wu:fj55d06
    Summary
    Predicted to enable L-malate dehydrogenase (NAD+) activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to act upstream of or within malate metabolic process. Predicted to be active in mitochondrion. Is expressed in alar plate midbrain region; brain; eye; immature eye; and musculature system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mdh2 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (33218330..33392170)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (33439235..33448259)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496525 Neighboring gene myosin, light chain 10, regulatory Neighboring gene collagen, type XXVI, alpha 1 Neighboring gene BAF chromatin remodeling complex subunit BCL7B a Neighboring gene transducin beta like 2 Neighboring gene PR domain containing 15 Neighboring gene C2 calcium dependent domain containing 2 Neighboring gene microRNA 301a-1 Neighboring gene microRNA 130a-1 Neighboring gene testis expressed 14, intercellular bridge forming factor Neighboring gene microRNA 454a Neighboring gene zgc:153345 Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene uncharacterized LOC137496526 Neighboring gene ryanodine receptor 1a (skeletal)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Targeted toxicometabolomics of endosulfan sulfate in adult zebrafish (Danio rerio) using GC-MS/MS in multiple reaction monitoring mode. Lee HK, et al. J Hazard Mater, 2020 May 5. PMID 32000124
    2. Proteome profile of zebrafish Danio rerio olfactory bulb based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis. Singh SK, et al. Zebrafish, 2011 Dec. PMID 22181661
    3. Characterization of Biological Pathways Regulating Acute Cold Resistance of Zebrafish. Ren J, et al. Int J Mol Sci, 2021 Mar 16. PMID 33809683, Free PMC Article
    4. In vivo identification of potential uranium protein targets in zebrafish ovaries after chronic waterborne exposure. Eb-Levadoux Y, et al. Metallomics, 2017 May 24. PMID 28317950
    5. Proteomic analysis of the Rett syndrome experimental model mecp2(Q63X) mutant zebrafish. Cortelazzo A, et al. J Proteomics, 2017 Feb 10. PMID 28062374

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-malate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-malate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables malate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within malate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    malate dehydrogenase, mitochondrial
    NP_998296.1
    XP_068079862.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213131.1 → NP_998296.1  malate dehydrogenase, mitochondrial

      See identical proteins and their annotated locations for NP_998296.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053272
      UniProtKB/TrEMBL
      A0A8M1PNU6, Q7T334
      Related
      ENSDARP00000063661.4, ENSDART00000063662.6
      Conserved Domains (2) summary
      cd01337
      Location:25 → 333
      MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases
      PLN00106
      Location:6 → 328
      PLN00106; malate dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      33218330..33392170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223761.1 → XP_068079862.1  malate dehydrogenase, mitochondrial isoform X1

    Nucleotide Protein
    Heading Accession and Version

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