ptk2aa protein tyrosine kinase 2aa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptk2aaprovided by ZNC
Official Full Name: protein tyrosine kinase 2aaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031114-5
See related: AllianceGenome:ZFIN:ZDB-GENE-031114-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fak1b; ptk2b; ptk2.2; si:ch1073-355e8.1
Summary: Predicted to enable ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within regulation of protein localization. Predicted to be located in several cellular components, including cytoskeleton; focal adhesion; and plasma membrane. Is expressed in head; midbrain; midbrain hindbrain boundary; and paraxial mesoderm. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (1743043..1848494)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (1797587..1898639)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fc14h12.x1 (e-PCR)
- UniSTS:192702

Z7964 (e-PCR)
- UniSTS:31434

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in developmental process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular component organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein localization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal complex assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein tyrosine kinase 2aa

Names: fakb; protein tyrosine kinase 2.2; protein tyrosine kinase 2b

NP_942114.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198819.1 → NP_942114.1 protein tyrosine kinase 2aa

See identical proteins and their annotated locations for NP_942114.1

Status: PROVISIONAL

Source sequence(s)

AY196213

UniProtKB/TrEMBL

Q7T2V4

Conserved Domains (6) summary

cd05056
Location:419 → 688

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00295
Location:36 → 258

B41; Band 4.1 homologues

cd13190
Location:254 → 364

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

cd14473
Location:143 → 247

FERM_B-lobe; FERM domain B-lobe

pfam03623
Location:911 → 1040

Focal_AT; Focal adhesion targeting region

pfam07714
Location:426 → 680

Pkinase_Tyr; Protein tyrosine kinase