tmx2b thioredoxin-related transmembrane protein 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tmx2bprovided by ZNC
Official Full Name: thioredoxin-related transmembrane protein 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040625-105
See related: Ensembl:ENSDARG00000007786 AllianceGenome:ZFIN:ZDB-GENE-040625-105
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tmx2; fb73h06; txndc14; zgc:86830; wu:fb73h06
Summary: Predicted to enable disulfide oxidoreductase activity. Predicted to be involved in brain development. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be active in mitochondria-associated endoplasmic reticulum membrane contact site. Orthologous to human TMX2 (thioredoxin related transmembrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (44570705..44581937, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (43869402..43880634, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables disulfide oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondria-associated endoplasmic reticulum membrane contact site	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thioredoxin-related transmembrane protein 2-B

Names: thioredoxin domain containing 14; thioredoxin domain-containing protein 14; thioredoxin-related transmembrane protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002113.1 → NP_001002113.1 thioredoxin-related transmembrane protein 2-B precursor

See identical proteins and their annotated locations for NP_001002113.1

Status: PROVISIONAL

Source sequence(s)

BC071481

UniProtKB/Swiss-Prot

B8A5B2, Q6IQC7

Related

ENSDARP00000022891.5, ENSDART00000009858.6

Conserved Domains (1) summary

cd02962
Location:109 → 259

TMX2; TMX2 family; composed of proteins similar to human TMX2, a 372-amino acid TRX-related transmembrane protein, identified and characterized through the cloning of its cDNA from a human fetal library. It contains a TRX domain but the redox active CXXC motif ...