U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tmem38b transmembrane protein 38B [ Danio rerio (zebrafish) ]

    Gene ID: 393145, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tmem38bprovided by ZNC
    Official Full Name
    transmembrane protein 38Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-807
    See related
    AllianceGenome:ZFIN:ZDB-GENE-040426-807
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    TRICB; zgc:55815
    Summary
    Predicted to enable potassium channel activity. Predicted to be involved in regulation of release of sequestered calcium ion into cytosol. Predicted to act upstream of or within potassium ion transmembrane transport. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 14. Orthologous to human TMEM38B (transmembrane protein 38B). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See tmem38b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (564911..589018, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (347244..371351)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene NOP14 nucleolar protein homolog (yeast) Neighboring gene vimentin Neighboring gene inactive tyrosine-protein kinase PRAG1 Neighboring gene inactive tyrosine-protein kinase PRAG1-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Zebrafish Tric-b is required for skeletal development and bone cells differentiation. Tonelli F, et al. Front Endocrinol (Lausanne), 2023. PMID 36755921, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zebrafish Tric-b is required for skeletal development and bone cells differentiation.
      Title: Zebrafish Tric-b is required for skeletal development and bone cells differentiation.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC55815

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fin regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of bone development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    trimeric intracellular cation channel type B
    Names
    TRIC-B

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200176.1 → NP_956470.1  trimeric intracellular cation channel type B

      See identical proteins and their annotated locations for NP_956470.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045460
      UniProtKB/Swiss-Prot
      Q7ZVP8
      Conserved Domains (1) summary
      pfam05197
      Location:43 → 224
      TRIC; TRIC channel

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      564911..589018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZVP8.1 GenPept UniProtKB/Swiss-Prot:Q7ZVP8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials