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    mepcea methylphosphate capping enzyme a [ Danio rerio (zebrafish) ]

    Gene ID: 561384, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mepceaprovided by ZNC
    Official Full Name
    methylphosphate capping enzyme aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3936
    See related
    Ensembl:ENSDARG00000059461 AllianceGenome:ZFIN:ZDB-GENE-030131-3936
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mepce; fc59f06; zBCDIN3; wu:fc59f06; si:ch211-283h6.1
    Summary
    Predicted to enable RNA 5'-gamma-phosphate methyltransferase activity and snRNA binding activity. Predicted to be involved in RNA modification; positive regulation of protein localization to Cajal body; and positive regulation of snRNA transcription by RNA polymerase II. Predicted to act upstream of or within methylation. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Is expressed in blastoderm cell and brain. Orthologous to human MEPCE (methylphosphate capping enzyme). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mepcea in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (68766456..68782644, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (67995789..68011974, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene eph receptor B4a Neighboring gene disks large homolog 4 Neighboring gene uncharacterized LOC137495660 Neighboring gene hairy-related 1 Neighboring gene hairy and enhancer of split related-7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development. Barboric M, et al. Proc Natl Acad Sci U S A, 2009 May 12. PMID 19416841, Free PMC Article
    2. Expressed sequence tag analysis of expression profiles of zebrafish testis and ovary. Zeng S, et al. Gene, 2002 Jul 10. PMID 12234666
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA 5'-gamma-phosphate methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein localization to Cajal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of snRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in snRNA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in snRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    7SK snRNA methylphosphate capping enzyme
    Names
    bcdin3
    bicoid-interacting protein 3 homolog
    bin3 homolog
    bin3, bicoid-interacting 3
    NP_001122001.1
    XP_021331887.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128529.1 → NP_001122001.1  7SK snRNA methylphosphate capping enzyme

      Status: PROVISIONAL

      Source sequence(s)
      BX537304
      UniProtKB/Swiss-Prot
      A3KQ55
      UniProtKB/TrEMBL
      A0A0A0MPU6, A0A8M1NI31
      Related
      ENSDARP00000121674.1, ENSDART00000141699.2
      Conserved Domains (2) summary
      pfam06859
      Location:588 → 695
      Bin3; Bicoid-interacting protein 3 (Bin3)
      pfam13649
      Location:404 → 455
      Methyltransf_25; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      68766456..68782644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476212.2 → XP_021331887.1  7SK snRNA methylphosphate capping enzyme isoform X1

      UniProtKB/Swiss-Prot
      A3KQ55
      UniProtKB/TrEMBL
      A0A0A0MPU6, A0A8M1NI31
      Related
      ENSDARP00000146264.1, ENSDART00000192636.1
      Conserved Domains (2) summary
      pfam06859
      Location:588 → 695
      Bin3; Bicoid-interacting protein 3 (Bin3)
      pfam13649
      Location:404 → 455
      Methyltransf_25; Methyltransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A3KQ55.2 GenPept UniProtKB/Swiss-Prot:A3KQ55

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