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    orc6 origin recognition complex, subunit 6 [ Danio rerio (zebrafish) ]

    Gene ID: 324256, updated on 9-Dec-2024

    Summary

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    Official Symbol
    orc6provided by ZNC
    Official Full Name
    origin recognition complex, subunit 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2976
    See related
    Ensembl:ENSDARG00000075682 AllianceGenome:ZFIN:ZDB-GENE-030131-2976
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    orc6l; zgc:65798; zgc:77185; wu:fa94a09; wu:fc22h10
    Summary
    Predicted to enable DNA binding activity. Acts upstream of or within cilium assembly. Predicted to be located in nucleus. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in central nervous system; eye; intermediate cell mass of mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 3. Orthologous to human ORC6 (origin recognition complex subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See orc6 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (41812479..41825625)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (41532440..41541288)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene histamine receptor H3 Neighboring gene VPS35 retromer complex component Neighboring gene myosin light chain kinase 3 Neighboring gene zgc:92818 Neighboring gene glutamic pyruvate transaminase (alanine aminotransferase) 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Analysis of cilia dysfunction phenotypes in zebrafish embryos depleted of Origin recognition complex factors. Maerz LD, et al. Eur J Hum Genet, 2019 May. PMID 30696958, Free PMC Article
    2. Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain Tumors. Idilli AI, et al. Cancers (Basel), 2020 Apr 22. PMID 32331249, Free PMC Article
    3. DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos. Jacob V, et al. Development, 2015 Feb 1. PMID 25564650, Free PMC Article
    4. DNA hypomethylation activates Cdk4/6 and Atr to induce DNA replication and cell cycle arrest to constrain liver outgrowth in zebrafish. Madakashira BP, et al. Nucleic Acids Res, 2024 Apr 12. PMID 38321933, Free PMC Article
    5. Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Leontovich AA, et al. J Diabetes Res, 2016. PMID 26981540, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear origin of replication recognition complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    origin recognition complex subunit 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212671.2 → NP_997836.1  origin recognition complex subunit 6

      See identical proteins and their annotated locations for NP_997836.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056528
      UniProtKB/TrEMBL
      Q6P0G9, Q6ZM36
      Related
      ENSDARP00000101426.2, ENSDART00000113732.3
      Conserved Domains (2) summary
      cd11583
      Location:93 → 184
      Orc6_mid; Middle domain of the origin recognition complex subunit 6
      pfam05460
      Location:6 → 93
      ORC6; Origin recognition complex subunit 6 (ORC6)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      41812479..41825625
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222167.1 → XP_068078268.1  origin recognition complex subunit 6 isoform X1

      UniProtKB/TrEMBL
      Q6P0G9, Q6ZM36
      Related
      ENSDARP00000143032.1, ENSDART00000174137.2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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