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    mvp major vault protein [ Danio rerio (zebrafish) ]

    Gene ID: 373081, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mvpprovided by ZNC
    Official Full Name
    major vault proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030826-33
    See related
    Ensembl:ENSDARG00000021242 AllianceGenome:ZFIN:ZDB-GENE-030826-33
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb771; wu:fb52b05; wu:fc02g01
    Summary
    Acts upstream of or within cranial skeletal system development; eye development; and nervous system development. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; hatching gland; nervous system; periderm; and polster. Orthologous to human MVP (major vault protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mvp in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (15708370..15734386, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (15558572..15584725, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene zgc:66443 Neighboring gene proline-rich transmembrane protein 2 Neighboring gene prohibitin Neighboring gene zinc finger protein 652

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The major vault protein is dispensable for zebrafish organ regeneration. Zhang X, et al. Heliyon, 2020 Nov. PMID 33195847, Free PMC Article
    2. Zebrafish MVP Recruits and Degrades TBK1 To Suppress IFN Production. Li S, et al. J Immunol, 2019 Jan 15. PMID 30530482
    3. Major vault protein promotes locomotor recovery and regeneration after spinal cord injury in adult zebrafish. Pan HC, et al. Eur J Neurosci, 2013 Jan. PMID 23106570
    4. Tracking genome-editing and associated molecular perturbations by SWATH mass spectrometry. Lin Q, et al. Sci Rep, 2019 Oct 23. PMID 31645615, Free PMC Article
    5. Oligogenic Effects of 16p11.2 Copy-Number Variation on Craniofacial Development. Qiu Y, et al. Cell Rep, 2019 Sep 24. PMID 31553903, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MVP is a negative regulator of IFN production by restricting the activation of TBK1
      Title: Zebrafish MVP Recruits and Degrades TBK1 To Suppress IFN Production.
    2. MVP is beneficial for functional recovery and axonal regrowth after spinal cord injury in adult zebrafish.
      Title: Major vault protein promotes locomotor recovery and regeneration after spinal cord injury in adult zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cranial skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron projection regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    major vault protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201325.2 → NP_958482.1  major vault protein

      See identical proteins and their annotated locations for NP_958482.1

      Status: VALIDATED

      Source sequence(s)
      BX936308
      UniProtKB/Swiss-Prot
      Q6P3L0, Q7ZUB4
      Related
      ENSDARP00000115387.1, ENSDART00000137325.3
      Conserved Domains (6) summary
      PTZ00491
      Location:10 → 859
      PTZ00491; major vault protein; Provisional
      cd08825
      Location:523 → 674
      MVP_shoulder; Shoulder domain of the major vault protein
      pfam01505
      Location:118 → 157
      Vault; Major Vault Protein repeat
      cd16269
      Location:802 → 814
      GBP_C; coiled coil [structural motif]
      cl19107
      Location:626 → 754
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      cl20817
      Location:703 → 827
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      15708370..15734386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163803.5 → XP_005163860.1  major vault protein isoform X1

      UniProtKB/TrEMBL
      A0A8M2BB27, E9QEQ6
      Related
      ENSDARP00000112736.1, ENSDART00000141142.2
      Conserved Domains (6) summary
      PTZ00491
      Location:16 → 866
      PTZ00491; major vault protein; Provisional
      cd08825
      Location:530 → 681
      MVP_shoulder; Shoulder domain of the major vault protein
      pfam01505
      Location:124 → 163
      Vault; Major Vault Protein repeat
      cd16269
      Location:809 → 821
      GBP_C; coiled coil [structural motif]
      cl19107
      Location:633 → 761
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      cl20817
      Location:710 → 834
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P3L0.1 GenPept UniProtKB/Swiss-Prot:Q6P3L0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.