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    cttnbp2 cortactin binding protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 555837, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cttnbp2provided by ZNC
    Official Full Name
    cortactin binding protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8134
    See related
    Ensembl:ENSDARG00000040991 AllianceGenome:ZFIN:ZDB-GENE-030131-8134
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj55a11; wu:fj55a11; si:dkey-270i2.3
    Summary
    Predicted to be involved in regulation of synapse organization. Predicted to be located in cell cortex and dendritic spine. Predicted to be active in glutamatergic synapse. Is expressed in anterior macula. Orthologous to human CTTNBP2 (cortactin binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cttnbp2 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (20725264..20821870, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (20736198..20832829, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat, SAM and basic leucine zipper domain containing 1 Neighboring gene CF transmembrane conductance regulator Neighboring gene uncharacterized LOC137488275 Neighboring gene tetratricopeptide repeat domain 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Analysis and functional evaluation of the hair-cell transcriptome. McDermott BM Jr, et al. Proc Natl Acad Sci U S A, 2007 Jul 10. PMID 17606911, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in regulation of synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cortactin-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      20725264..20821870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467802.2 → XP_021323477.1  cortactin-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9P1C3, F1QFV1
      Related
      ENSDARP00000091516.3, ENSDART00000100743.5
      Conserved Domains (7) summary
      cd00204
      Location:679 → 796
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:679 → 707
      ANK; ANK repeat [structural motif]
      pfam09727
      Location:35 → 180
      CortBP2; Cortactin-binding protein-2
      pfam12796
      Location:617 → 707
      Ank_2; Ankyrin repeats (3 copies)
      pfam15991
      Location:216 → 463
      G_path_suppress; G-protein pathway suppressor
      cl25732
      Location:123 → 272
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26464
      Location:400 → 629
      Atrophin-1; Atrophin-1 family

    2. XM_068214902.1 → XP_068071003.1  cortactin-binding protein 2 isoform X2

      Related
      ENSDARP00000119895.1, ENSDART00000143233.2

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395022.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      322622..418397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_678481.8 → XP_683573.5  cortactin-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8N7T6Y9
      Conserved Domains (7) summary
      cd00204
      Location:679 → 796
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:679 → 707
      ANK; ANK repeat [structural motif]
      pfam09727
      Location:35 → 180
      CortBP2; Cortactin-binding protein-2
      pfam12796
      Location:617 → 707
      Ank_2; Ankyrin repeats (3 copies)
      pfam15991
      Location:216 → 463
      G_path_suppress; G-protein pathway suppressor
      cl25742
      Location:119 → 273
      ERM; Ezrin/radixin/moesin family
      cl26464
      Location:400 → 629
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein Strain
    Heading Accession and Version

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