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    adam17a ADAM metallopeptidase domain 17a [ Danio rerio (zebrafish) ]

    Gene ID: 324142, updated on 9-Dec-2024

    Summary

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    Official Symbol
    adam17aprovided by ZNC
    Official Full Name
    ADAM metallopeptidase domain 17aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2862
    See related
    Ensembl:ENSDARG00000043213 AllianceGenome:ZFIN:ZDB-GENE-030131-2862
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc20b01; zgc:63886; wu:fc20b01
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in Notch signaling pathway and membrane protein ectodomain proteolysis. Predicted to act upstream of or within integrin-mediated signaling pathway and proteolysis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See adam17a in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (35247497..35278763, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (35299551..35330969, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene integrin beta 1 binding protein 1 Neighboring gene isoamyl acetate hydrolyzing esterase 1 (putative) Neighboring gene ring finger protein 144aa Neighboring gene radical S-adenosyl methionine domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ADAM12-deficient zebrafish exhibit retardation in body growth at the juvenile stage without developmental defects. Tokumasu Y, et al. Dev Growth Differ, 2016 May. PMID 27185351
    2. The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. Huxley-Jones J, et al. BMC Evol Biol, 2007 Apr 17. PMID 17439641, Free PMC Article
    3. Pigmentation pathway evolution after whole-genome duplication in fish. Braasch I, et al. Genome Biol Evol, 2009 Nov 25. PMID 20333216, Free PMC Article
    4. A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Xue Y, et al. Cell Rep, 2019 Apr 30. PMID 31042481
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 17a
    Names
    DKEY-174C12.1
    a disintegrin and metalloproteinase domain 17a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199673.1 → NP_955967.1  disintegrin and metalloproteinase domain-containing protein 17a precursor

      See identical proteins and their annotated locations for NP_955967.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057410
      UniProtKB/TrEMBL
      Q6PFU9
      Related
      ENSDARP00000063436.3, ENSDART00000063437.4
      Conserved Domains (5) summary
      cd04270
      Location:233 → 486
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam00200
      Location:493 → 567
      Disintegrin; Disintegrin
      pfam01562
      Location:62 → 161
      Pep_M12B_propep; Reprolysin family propeptide
      pfam13574
      Location:257 → 471
      Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
      pfam16698
      Location:590 → 648
      ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      35247497..35278763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158718.5 → XP_005158775.1  disintegrin and metalloproteinase domain-containing protein 17a isoform X1

      UniProtKB/TrEMBL
      A0A2R8Q3V6, A0A8M2B5L3
      Related
      ENSDARP00000147741.1, ENSDART00000181587.1
      Conserved Domains (5) summary
      cd04270
      Location:233 → 486
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam00200
      Location:493 → 567
      Disintegrin; Disintegrin
      pfam01562
      Location:62 → 161
      Pep_M12B_propep; Reprolysin family propeptide
      pfam13574
      Location:257 → 471
      Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
      pfam16698
      Location:590 → 648
      ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17
    Nucleotide Protein Strain
    Heading Accession and Version

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