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    stard3 StAR related lipid transfer domain containing 3 [ Danio rerio (zebrafish) ]

    Gene ID: 63998, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stard3provided by ZNC
    Official Full Name
    StAR related lipid transfer domain containing 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-001120-2
    See related
    Ensembl:ENSDARG00000017809 AllianceGenome:ZFIN:ZDB-GENE-001120-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mln64; fc66d12; wu:fc66d12
    Summary
    Predicted to enable cholesterol binding activity and protein homodimerization activity. Predicted to be involved in cholesterol transport and vesicle tethering to endoplasmic reticulum. Predicted to act upstream of or within lipid transport. Predicted to be located in organelle membrane contact site. Predicted to be active in endoplasmic reticulum-endosome membrane contact site and late endosome membrane. Predicted to colocalize with endoplasmic reticulum membrane. Is expressed in yolk syncytial layer. Orthologous to human STARD3 (StAR related lipid transfer domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See stard3 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (4968947..4985996)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (5052461..5069510)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 12 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 1B Neighboring gene zgc:91968 Neighboring gene chromodomain helicase DNA binding protein 4a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Conservation of steroidogenic acute regulatory (StAR) protein structure and expression in vertebrates. Bauer MP, et al. Mol Cell Endocrinol, 2000 Oct 25. PMID 11064158
    2. Zebrafish microRNA miR-210-5p inhibits primitive myelopoiesis by silencing foxj1b and slc3a2a mRNAs downstream of gata4/5/6 transcription factor genes. Jia W, et al. J Biol Chem, 2019 Feb 22. PMID 30593510, Free PMC Article
    3. Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes. Garcia-Reyero N, et al. Bull Environ Contam Toxicol, 2016 Jun. PMID 27086301, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cholesterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cholesterol transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle tethering to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle tethering to endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum-endosome membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-endosome membrane contact site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in organelle membrane contact site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    stAR-related lipid transfer protein 3
    Names
    START domain containing 3
    START domain-containing protein 3
    StAR-related lipid transfer (START) domain containing 3
    mln64-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131662.1 → NP_571737.1  stAR-related lipid transfer protein 3

      See identical proteins and their annotated locations for NP_571737.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056766
      UniProtKB/Swiss-Prot
      Q6PH03, Q9DFS4
      Related
      ENSDARP00000007948.6, ENSDART00000003634.8
      Conserved Domains (2) summary
      cd08906
      Location:235 → 443
      START_STARD3-like; Cholesterol-binding START domain of mammalian STARD3 and related proteins
      pfam10457
      Location:48 → 214
      MENTAL; Cholesterol-capturing domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      4968947..4985996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159353.5 → XP_005159410.1  stAR-related lipid transfer protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005159410.1

      UniProtKB/Swiss-Prot
      Q6PH03, Q9DFS4
      Conserved Domains (2) summary
      cd08906
      Location:235 → 443
      START_STARD3-like; Cholesterol-binding START domain of mammalian STARD3 and related proteins
      pfam10457
      Location:48 → 214
      MENTAL; Cholesterol-capturing domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DFS4.2 GenPept UniProtKB/Swiss-Prot:Q9DFS4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.