tapt1b transmembrane anterior posterior transformation 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tapt1bprovided by ZNC
Official Full Name: transmembrane anterior posterior transformation 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4025
See related: Ensembl:ENSDARG00000061143 AllianceGenome:ZFIN:ZDB-GENE-030131-4025
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tapt1; fc65g11; wu:fc65g11; si:dkey-92j12.3
Summary: Involved in several processes, including positive regulation of bone development; positive regulation of cartilage development; and positive regulation of cilium assembly. Acts upstream of or within several processes, including camera-type eye morphogenesis; cranial skeletal system development; and ossification. Predicted to be located in centrosome and ciliary basal body. Is expressed in head kidney; mesenchyme pectoral fin; oocyte; and oral cavity. Orthologous to human TAPT1 (transmembrane anterior posterior transformation 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (22770255..22803147, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (22079516..22112408, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A tapt1 knock-out zebrafish line with aberrant lens development and impaired vision models human early-onset cataract.
Title: A tapt1 knock-out zebrafish line with aberrant lens development and impaired vision models human early-onset cataract.
Genetic Defects in TAPT1 Disrupt Ciliogenesis and Cause a Complex Lethal Osteochondrodysplasia.
Title: Genetic Defects in TAPT1 Disrupt Ciliogenesis and Cause a Complex Lethal Osteochondrodysplasia.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cranial skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within developmental pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens morphogenesis in camera-type eye	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neural crest cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of bone development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within retina layer formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane anterior posterior transformation protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.