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    acaca acetyl-CoA carboxylase alpha [ Danio rerio (zebrafish) ]

    Gene ID: 559403, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acacaprovided by ZNC
    Official Full Name
    acetyl-CoA carboxylase alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060526-74
    See related
    Ensembl:ENSDARG00000078512 AllianceGenome:ZFIN:ZDB-GENE-060526-74
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    acc; fj43d01; im:7138837; wu:fj43d01; si:ch211-199d18.1
    Summary
    Predicted to enable acetyl-CoA carboxylase activity. Acts upstream of or within response to (R)-carnitine. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in liver; male organism; subcutaneous fat; and visceral fat. Orthologous to human ACACA (acetyl-CoA carboxylase alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See acaca in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (56308616..56416176, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (55638405..55746037, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene LIM homeobox 1b Neighboring gene apoptosis antagonizing transcription factor Neighboring gene T-box transcription factor 2a Neighboring gene uncharacterized LOC137490762

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Effects of dietary biotin and avidin on growth, survival, feed conversion, biotin status and gene expression of zebrafish Danio rerio. Yossa R, et al. Comp Biochem Physiol B Biochem Mol Biol, 2011 Dec. PMID 21839851
    2. Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice. Karanth S, et al. Dis Model Mech, 2013 Nov. PMID 24057001, Free PMC Article
    3. Vitamin C inhibits lipid deposition through GSK-3β/mTOR signaling in the liver of zebrafish. Liu D, et al. Fish Physiol Biochem, 2020 Feb. PMID 31782040
    4. Transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish. Archer A, et al. Dev Dyn, 2008 Apr. PMID 18297735
    5. Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish. Jia JY, et al. Zool Res, 2024 Mar 18. PMID 38485505, Free PMC Article

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetyl-CoA carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in malonyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to (R)-carnitine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acetyl-CoA carboxylase 1
    Names
    acetyl-Coenzyme A carboxylase alpha
    NP_001258237.1
    XP_017211598.1
    XP_017211600.1
    XP_017211601.1
    XP_017211602.1
    XP_017211603.1
    XP_017211604.1
    XP_017211606.1
    XP_021331867.1
    XP_021331868.1
    XP_021331869.1
    XP_021331870.1
    XP_021331871.1
    XP_021331872.1
    XP_021331873.1
    XP_021331874.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271308.1 → NP_001258237.1  acetyl-CoA carboxylase 1

      Status: PROVISIONAL

      Source sequence(s)
      AL935115, BX255908
      UniProtKB/TrEMBL
      A0A8M1NZ82, A0A8M9QE20, F1QH12
      Related
      ENSDARP00000077514.5, ENSDART00000083079.6
      Conserved Domains (7) summary
      COG0439
      Location:118 → 621
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00289
      Location:118 → 237
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:753 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1712 → 2266
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:507 → 614
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:820 → 1612
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:279 → 470
      ATP-grasp_4; ATP-grasp domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      56308616..56416176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476199.2 → XP_021331874.1  acetyl-CoA carboxylase 1 isoform X12

      UniProtKB/TrEMBL
      A0A8M9Q3F9, A0A8M9QE20
      Conserved Domains (4) summary
      COG0439
      Location:118 → 621
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:753 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1670 → 2224
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:820 → 1563
      ACC_central; Acetyl-CoA carboxylase, central region

    2. XM_021476197.2 → XP_021331872.1  acetyl-CoA carboxylase 1 isoform X7

      UniProtKB/TrEMBL
      A0A8M9PK85, A0A8M9QE20
      Conserved Domains (4) summary
      COG0439
      Location:118 → 621
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:753 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1705 → 2259
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:820 → 1598
      ACC_central; Acetyl-CoA carboxylase, central region

    3. XM_017356115.3 → XP_017211604.1  acetyl-CoA carboxylase 1 isoform X13

      UniProtKB/TrEMBL
      A0A8M6Z6C9, A0A8M9QE20

    4. XM_021476198.2 → XP_021331873.1  acetyl-CoA carboxylase 1 isoform X8

      UniProtKB/TrEMBL
      A0A8M9PXQ3, A0A8M9QE20
      Conserved Domains (4) summary
      COG0439
      Location:118 → 621
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:753 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1698 → 2252
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:820 → 1591
      ACC_central; Acetyl-CoA carboxylase, central region

    5. XM_017356117.3 → XP_017211606.1  acetyl-CoA carboxylase 1 isoform X14

      UniProtKB/TrEMBL
      A0A8M6YZ52, A0A8M9QE20

    6. XM_017356114.3 → XP_017211603.1  acetyl-CoA carboxylase 1 isoform X11

      UniProtKB/TrEMBL
      A0A8M6YY91, A0A8M9QE20

    7. XM_021476196.2 → XP_021331871.1  acetyl-CoA carboxylase 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q8Q1, A0A8M9QE20
      Conserved Domains (4) summary
      COG0439
      Location:118 → 621
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:753 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1713 → 2267
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:820 → 1606
      ACC_central; Acetyl-CoA carboxylase, central region

    8. XM_017356113.3 → XP_017211602.1  acetyl-CoA carboxylase 1 isoform X10

      UniProtKB/TrEMBL
      A0A8M6Z6X1, A0A8M9QE20

    9. XM_017356112.3 → XP_017211601.1  acetyl-CoA carboxylase 1 isoform X9

      UniProtKB/TrEMBL
      A0A2R8QJA0, A0A8M6Z0L9, A0A8M9QE20

    10. XM_021476195.2 → XP_021331870.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9QE14, A0A8M9QE20
      Conserved Domains (4) summary
      COG0439
      Location:118 → 621
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:753 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1732 → 2286
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:820 → 1625
      ACC_central; Acetyl-CoA carboxylase, central region

    11. XM_017356111.3 → XP_017211600.1  acetyl-CoA carboxylase 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M6YZ47, A0A8M9QE20, F6P055
      Related
      ENSDARP00000122142.2, ENSDART00000146773.4

    12. XM_017356109.3 → XP_017211598.1  acetyl-CoA carboxylase 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M1NZ82, A0A8M9QE20, F1QH12
      Conserved Domains (7) summary
      COG0439
      Location:118 → 621
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00289
      Location:118 → 237
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:753 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1712 → 2266
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:507 → 614
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:820 → 1612
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:279 → 470
      ATP-grasp_4; ATP-grasp domain

    13. XM_021476194.2 → XP_021331869.1  acetyl-CoA carboxylase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q3F2, A0A8M9QE20
      Conserved Domains (4) summary
      COG0439
      Location:118 → 621
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:753 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1740 → 2294
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:820 → 1633
      ACC_central; Acetyl-CoA carboxylase, central region

    14. XM_021476192.2 → XP_021331867.1  acetyl-CoA carboxylase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PK80, A0A8M9QE20
      Conserved Domains (4) summary
      COG0439
      Location:118 → 621
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:753 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1747 → 2301
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:820 → 1640
      ACC_central; Acetyl-CoA carboxylase, central region

    15. XM_021476193.2 → XP_021331868.1  acetyl-CoA carboxylase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PK80, A0A8M9QE20
      Conserved Domains (4) summary
      COG0439
      Location:118 → 621
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:753 → 818
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:1747 → 2301
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:820 → 1640
      ACC_central; Acetyl-CoA carboxylase, central region

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394614.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      50377..161998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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