slc5a8l solute carrier family 5 member 8, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc5a8lprovided by ZNC
Official Full Name: solute carrier family 5 member 8, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061110-98
See related: Ensembl:ENSDARG00000003697 AllianceGenome:ZFIN:ZDB-GENE-061110-98
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: smcte; slc5a8; wu:fd59e02; zgc:152716
Summary: Enables monocarboxylate:sodium symporter activity. Involved in lactate transport; nicotinate transport; and pyruvate transport. Acts upstream of or within carboxylic acid transmembrane transport and monocarboxylic acid transport. Predicted to be located in apical plasma membrane. Is expressed in several structures, including immature eye; male organism; nervous system; neurocranial trabecula; and pleuroperitoneal region. Orthologous to human SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (49063289..49078263, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (49064636..49079610, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables monocarboxylate:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic acid:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables secondary active monocarboxylate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in chloride transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in iodide transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in lactate transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in nicotinate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in nitrate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in propanoate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in propanoate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyruvate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sodium-coupled monocarboxylate transporter 1

Names: electrogenic sodium monocarboxylate cotransporter; sodium solute symporter family 5 member 8 protein; solute carrier family 5 (iodide transporter), member 8-like; zSMCTe

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034969.1 → NP_001030141.1 sodium-coupled monocarboxylate transporter 1

See identical proteins and their annotated locations for NP_001030141.1

Status: PROVISIONAL

Source sequence(s)

AY727859

UniProtKB/Swiss-Prot

A0AUP7, Q3ZMH1

Related

ENSDARP00000030637.6, ENSDART00000032982.8

Conserved Domains (1) summary

cd11519
Location:8 → 547

SLC5sbd_SMCT1; Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain