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    phldb2b pleckstrin homology-like domain, family B, member 2b [ Danio rerio (zebrafish) ]

    Gene ID: 560668, updated on 9-Dec-2024

    Summary

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    Official Symbol
    phldb2bprovided by ZNC
    Official Full Name
    pleckstrin homology-like domain, family B, member 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3235
    See related
    Ensembl:ENSDARG00000074843 AllianceGenome:ZFIN:ZDB-GENE-030131-3235
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc31d06; wu:fc31d06; si:dkey-11p10.8
    Summary
    Predicted to be involved in regulation of microtubule cytoskeleton organization. Predicted to be active in basal cortex. Orthologous to human PHLDB2 (pleckstrin homology like domain family B member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See phldb2b in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (25093297..25166652, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (24948123..25021544, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 6 Neighboring gene APC membrane recruitment protein 2 Neighboring gene uncharacterized LOC108181555 Neighboring gene si:ch73-264p11.1 Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    pleckstrin homology-like domain family B member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      25093297..25166652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217225.1 → XP_068073326.1  pleckstrin homology-like domain family B member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9P651
      Related
      ENSDARP00000116815.2, ENSDART00000141601.4

    2. XM_021470325.2 → XP_021326000.1  pleckstrin homology-like domain family B member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PUG2, A0A8M9PXY1
      Conserved Domains (5) summary
      cd00060
      Location:51 → 149
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14673
      Location:1360 → 1464
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      cl25732
      Location:680 → 915
      SMC_N; RecF/RecN/SMC N terminal domain
      cl27427
      Location:986 → 1029
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      cl28033
      Location:189 → 500
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    3. XM_068217227.1 → XP_068073328.1  pleckstrin homology-like domain family B member 2 isoform X4

      UniProtKB/TrEMBL
      A0A8M9P651

    4. XM_068217226.1 → XP_068073327.1  pleckstrin homology-like domain family B member 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M9P651
    Nucleotide Protein Strain
    Heading Accession and Version

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