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    sart3 spliceosome associated factor 3, U4/U6 recycling protein [ Danio rerio (zebrafish) ]

    Gene ID: 558581, updated on 9-Dec-2024

    Summary

    Official Symbol
    sart3provided by ZNC
    Official Full Name
    spliceosome associated factor 3, U4/U6 recycling proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040724-10
    See related
    Ensembl:ENSDARG00000008032 AllianceGenome:ZFIN:ZDB-GENE-040724-10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    SART-3; unm_sm471; wu:fc51h03; zC191D15.4; si:ch211-191d15.4
    Summary
    Predicted to enable U6 snRNA binding activity and histone binding activity. Involved in spliceosomal snRNP assembly. Acts upstream of or within several processes, including exocrine pancreas development; hematopoietic stem cell homeostasis; and spliceosomal complex assembly. Predicted to be located in Cajal body. Predicted to be part of ASAP complex; U4/U6 snRNP; and U6atac snRNP. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human SART3 (spliceosome associated factor 3, U4/U6 recycling protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See sart3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (20448782..20481389)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (19944749..19977593)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 119a Neighboring gene iron-sulfur cluster assembly enzyme a Neighboring gene FIC domain protein adenylyltransferase Neighboring gene chemerin-like receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding  
    enables U6 snRNA binding  
    enables histone binding  
    enables nucleic acid binding  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA processing  
    acts_upstream_of_or_within RNA splicing  
    acts_upstream_of_or_within exocrine pancreas development PubMed 
    acts_upstream_of_or_within hematopoietic stem cell homeostasis PubMed 
    acts_upstream_of_or_within hematopoietic stem cell homeostasis PubMed 
    acts_upstream_of_or_within lymphocyte differentiation PubMed 
    acts_upstream_of_or_within mRNA processing  
    involved_in mRNA splicing, via spliceosome  
    involved_in mRNA splicing, via spliceosome  
    involved_in nucleosome assembly  
    acts_upstream_of_or_within regulation of hematopoietic stem cell proliferation PubMed 
    acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway by p53 class mediator PubMed 
    acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway by p53 class mediator PubMed 
    acts_upstream_of_or_within spliceosomal complex assembly PubMed 
    involved_in spliceosomal snRNP assembly PubMed 
    acts_upstream_of_or_within thymus development PubMed 
    involved_in transcription elongation-coupled chromatin remodeling  
    Component Evidence Code Pubs
    part_of ASAP complex  
    located_in Cajal body  
    part_of U4/U6 snRNP  
    part_of U6atac snRNP  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in nuclear speck  
    is_active_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    squamous cell carcinoma antigen recognized by T-cells 3
    Names
    earl grey
    egy
    p110
    squamous cell carcinoma antigen recognised by T cells 3
    squamous cell carcinoma antigen recognized by T cells 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030118.2 → NP_001025289.1  squamous cell carcinoma antigen recognized by T-cells 3

      Status: PROVISIONAL

      Source sequence(s)
      AL845326
      UniProtKB/TrEMBL
      A0A8M1N775, Q6ZM52
      Related
      ENSDARP00000004923.8, ENSDART00000008402.9
      Conserved Domains (6) summary
      smart00386
      Location:304 → 336
      HAT; HAT (Half-A-TPR) repeats
      COG0724
      Location:774 → 919
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      COG5107
      Location:62 → 496
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      cd12391
      Location:689 → 762
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:783 → 863
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam16605
      Location:861 → 920
      LSM_int_assoc; LSM-interacting associated unstructured

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      20448782..20481389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165154.5 → XP_005165211.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

      See identical proteins and their annotated locations for XP_005165211.1

      UniProtKB/Swiss-Prot
      B3DJT0
      Conserved Domains (6) summary
      smart00386
      Location:304 → 336
      HAT; HAT (Half-A-TPR) repeats
      COG0724
      Location:774 → 919
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      COG5107
      Location:62 → 496
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      cd12391
      Location:689 → 762
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:783 → 863
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam16605
      Location:861 → 920
      LSM_int_assoc; LSM-interacting associated unstructured
    2. XM_068221217.1 → XP_068077318.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

      UniProtKB/Swiss-Prot
      B3DJT0
    3. XM_017356104.3 → XP_017211593.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

      UniProtKB/Swiss-Prot
      B3DJT0
      Conserved Domains (6) summary
      smart00386
      Location:304 → 336
      HAT; HAT (Half-A-TPR) repeats
      COG0724
      Location:774 → 919
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      COG5107
      Location:62 → 496
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      cd12391
      Location:689 → 762
      RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      cd12392
      Location:783 → 863
      RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
      pfam16605
      Location:861 → 920
      LSM_int_assoc; LSM-interacting associated unstructured
    4. XM_068221218.1 → XP_068077319.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

      UniProtKB/Swiss-Prot
      B3DJT0
      Related
      ENSDARP00000106223.1, ENSDART00000124545.3
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