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    plk3 polo-like kinase 3 (Drosophila) [ Danio rerio (zebrafish) ]

    Gene ID: 334202, updated on 9-Dec-2024

    Summary

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    Official Symbol
    plk3provided by ZNC
    Official Full Name
    polo-like kinase 3 (Drosophila)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6134
    See related
    Ensembl:ENSDARG00000038754 AllianceGenome:ZFIN:ZDB-GENE-030131-6134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cnk; wu:fi35f10
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including Golgi disassembly; mitotic G1/S transition checkpoint signaling; and mitotic spindle organization. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in several cellular components, including kinetochore; microtubule cytoskeleton; and nucleus. Is expressed in liver; spinal cord; and spleen. Orthologous to human PLK3 (polo like kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See plk3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (35603654..35611791)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (35621197..35629332)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S14 Neighboring gene calcyclin binding protein Neighboring gene si:dkey-4i23.5 Neighboring gene dynein light chain Tctex-type 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Inhibition of Plk1 induces mitotic infidelity and embryonic growth defects in developing zebrafish embryos. Jeong K, et al. Dev Biol, 2010 Sep 1. PMID 20553902
    2. Screening and functional identification of lncRNAs under β-diketone antibiotic exposure to zebrafish (Danio rerio) using high-throughput sequencing. Wang X, et al. Aquat Toxicol, 2017 Jan. PMID 27951453
    3. Transcriptomics approach to investigate zebrafish heart regeneration. Sleep E, et al. J Cardiovasc Med (Hagerstown), 2010 May. PMID 20179605
    4. Immunotoxicity of β-Diketone Antibiotic Mixtures to Zebrafish (Danio rerio) by Transcriptome Analysis. Li F, et al. PLoS One, 2016. PMID 27046191, Free PMC Article
    5. A Pilot Single Cell Analysis of the Zebrafish Embryo Cellular Responses to Uropathogenic Escherichia coli Infection. Rawson A, et al. Pathog Immun, 2022. PMID 35178490, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic G1/S transition checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PLK3
    Names
    cytokine-inducible kinase
    NP_958465.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201308.2 → NP_958465.2  serine/threonine-protein kinase PLK3

      Status: VALIDATED

      Source sequence(s)
      FP015808
      UniProtKB/TrEMBL
      Q7ZVM4
      Related
      ENSDARP00000121537.1, ENSDART00000147278.2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      35603654..35611791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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