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    abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [ Danio rerio (zebrafish) ]

    Gene ID: 323301, updated on 9-Dec-2024

    Summary

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    Official Symbol
    abcc3provided by ZNC
    Official Full Name
    ATP-binding cassette, sub-family C (CFTR/MRP), member 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050517-16
    See related
    Ensembl:ENSDARG00000096662 AllianceGenome:ZFIN:ZDB-GENE-050517-16
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb94e12
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Orthologous to human ABCC3 (ATP binding cassette subfamily C member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See abcc3 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (695385..788152)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (689417..782211)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 2, cytosolic sulfotransferase 2 Neighboring gene Ras association and DIL domains 2b Neighboring gene WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2b Neighboring gene transducer of ERBB2, 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. MRP proteins as potential mediators of heavy metal resistance in zebrafish cells. Long Y, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2011 Apr. PMID 21147257
    2. Evolution of the vertebrate ABC gene family: analysis of gene birth and death. Annilo T, et al. Genomics, 2006 Jul. PMID 16631343
    3. Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. Dean M, et al. Annu Rev Genomics Hum Genet, 2005. PMID 16124856
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ABC-type glutathione S-conjugate transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family C member 3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      695385..788152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009306372.4 → XP_009304647.1  ATP-binding cassette sub-family C member 3 isoform X3

      UniProtKB/TrEMBL
      A0A8M3B4C9
      Conserved Domains (4) summary
      TIGR00957
      Location:10 → 1538
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1299 → 1519
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:640 → 841
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:985 → 1252
      ABC_membrane; ABC transporter transmembrane region

    2. XM_009306370.4 → XP_009304645.1  ATP-binding cassette sub-family C member 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AXY3
      Conserved Domains (4) summary
      TIGR00957
      Location:10 → 1539
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1300 → 1520
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:640 → 841
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:330 → 595
      ABC_membrane; ABC transporter transmembrane region

    3. XM_068224684.1 → XP_068080785.1  ATP-binding cassette sub-family C member 3 isoform X8

      Related
      ENSDARP00000139878.1, ENSDART00000161691.2

    4. XM_009306371.4 → XP_009304646.1  ATP-binding cassette sub-family C member 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B758
      Conserved Domains (4) summary
      TIGR00957
      Location:10 → 1538
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1299 → 1519
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:639 → 840
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:329 → 594
      ABC_membrane; ABC transporter transmembrane region

    5. XM_009306375.4 → XP_009304650.1  ATP-binding cassette sub-family C member 3 isoform X5

      UniProtKB/TrEMBL
      A0A8M3BDY5
      Conserved Domains (4) summary
      cd03250
      Location:640 → 841
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      COG1132
      Location:314 → 863
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      pfam00664
      Location:330 → 595
      ABC_membrane; ABC transporter transmembrane region
      cl00549
      Location:985 → 1107
      ABC_membrane; ABC transporter transmembrane region

    6. XM_009306374.4 → XP_009304649.1  ATP-binding cassette sub-family C member 3 isoform X4

      UniProtKB/TrEMBL
      A0A8M3AY17
      Conserved Domains (4) summary
      cd03250
      Location:640 → 841
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      COG1132
      Location:314 → 863
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      pfam00664
      Location:330 → 595
      ABC_membrane; ABC transporter transmembrane region
      cl00549
      Location:993 → 1139
      ABC_membrane; ABC transporter transmembrane region

    7. XM_068224683.1 → XP_068080784.1  ATP-binding cassette sub-family C member 3 isoform X7

    8. XM_068224682.1 → XP_068080783.1  ATP-binding cassette sub-family C member 3 isoform X6

    RNA

    1. XR_002459730.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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