aqp12 aquaporin 12 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aqp12provided by ZNC
Official Full Name: aquaporin 12provided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-310
See related: Ensembl:ENSDARG00000043279 AllianceGenome:ZFIN:ZDB-GENE-040718-310
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92747; wu:fb60e09; zgc:152755
Summary: Predicted to enable channel activity. Acts upstream of or within cellular response to estrogen stimulus. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including eye; gill; integument; liver; and pleuroperitoneal region. Orthologous to human AQP12A (aquaporin 12A) and AQP12B (aquaporin 12B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (2874831..2886946, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (2858565..2870680, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI497472 (e-PCR)
- UniSTS:206337

fb60e09 (e-PCR)
- UniSTS:187284

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aquaporin 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045862.2 → NP_001039327.1 aquaporin 12

See identical proteins and their annotated locations for NP_001039327.1

Status: VALIDATED

Source sequence(s)

BC076225, BC121752, BX324210

UniProtKB/TrEMBL

A0A8M1NAS4, Q0IIQ6

Related

ENSDARP00000063532.3, ENSDART00000063533.4

Conserved Domains (1) summary

cl00200
Location:41 → 243

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...