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    b4galt6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 [ Danio rerio (zebrafish) ]

    Gene ID: 393912, updated on 9-Dec-2024

    Summary

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    Official Symbol
    b4galt6provided by ZNC
    Official Full Name
    UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-789
    See related
    Ensembl:ENSDARG00000010301 AllianceGenome:ZFIN:ZDB-GENE-040426-789
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55730
    Summary
    Enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity. Acts upstream of or within glycosphingolipid metabolic process. Predicted to be located in Golgi cisterna membrane and Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human B4GALT6 (beta-1,4-galactosyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See b4galt6 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (6166495..6196989, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (6122637..6153515, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene pumilio RNA-binding family member 2 Neighboring gene transthyretin (prealbumin, amyloidosis type I) Neighboring gene finTRIM family, member 63 Neighboring gene opsin 7, group member a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A sensitive and reproducible assay to measure the activity of glucosylceramide synthase and lactosylceramide synthase using HPLC and fluorescent substrates. Hayashi Y, et al. Anal Biochem, 2005 Oct 15. PMID 16140251
    2. Transcriptional regulation in liver and testis associated with developmental and reproductive effects in male zebrafish exposed to natural mixtures of persistent organic pollutants (POP). Nourizadeh-Lillabadi R, et al. J Toxicol Environ Health A, 2009. PMID 19184727
    3. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC55730

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycosphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycosphingolipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,4-galactosyltransferase 6
    Names
    GalT
    NP_957232.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200938.1 → NP_957232.1  beta-1,4-galactosyltransferase 6

      See identical proteins and their annotated locations for NP_957232.1

      Status: PROVISIONAL

      Source sequence(s)
      BC046890
      UniProtKB/TrEMBL
      Q802Y5
      Related
      ENSDARP00000018673.8, ENSDART00000013343.8
      Conserved Domains (1) summary
      cd00899
      Location:154 → 370
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      6166495..6196989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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