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    dek DEK proto-oncogene [ Danio rerio (zebrafish) ]

    Gene ID: 692304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dekprovided by ZNC
    Official Full Name
    DEK proto-oncogeneprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060512-191
    See related
    Ensembl:ENSDARG00000070108 AllianceGenome:ZFIN:ZDB-GENE-060512-191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb82g12; zgc:136346
    Summary
    Predicted to enable histone binding activity. Predicted to be involved in regulation of double-strand break repair. Predicted to act upstream of or within chromatin organization. Predicted to be active in nucleus. Orthologous to human DEK (DEK proto-oncogene). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dek in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (41010978..41030634)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (41060936..41080602)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101885890 Neighboring gene glycogen synthase kinase binding protein Neighboring gene potassium voltage-gated channel modifier subfamily V member 1 Neighboring gene NF-kappa-B-activating protein-like Neighboring gene transfer RNA glutamic acid (anticodon CUC)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An essential role of variant histone H3.3 for ectomesenchyme potential of the cranial neural crest. Cox SG, et al. PLoS Genet, 2012 Sep. PMID 23028350, Free PMC Article
    2. Single-cell analyses identify distinct and intermediate states of zebrafish pancreatic islet development. Lu CJ, et al. J Mol Cell Biol, 2019 Jun 1. PMID 30407522, Free PMC Article
    3. A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery. Tiefenbach J, et al. PLoS One, 2010 Mar 22. PMID 20339547, Free PMC Article
    4. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC174609

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein DEK
    Names
    DEK oncogene
    DEK oncogene-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045276.2 → NP_001038741.2  protein DEK

      Status: VALIDATED

      Source sequence(s)
      BX511123
      UniProtKB/TrEMBL
      A0A8M1NAB4, F1R6C4
      Related
      ENSDARP00000058585.5, ENSDART00000058586.7
      Conserved Domains (1) summary
      pfam08766
      Location:390 → 442
      DEK_C; DEK C terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      41010978..41030634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292539.4 → XP_009290814.1  protein DEK isoform X1

      See identical proteins and their annotated locations for XP_009290814.1

      UniProtKB/TrEMBL
      A0A8M3AID6
      Conserved Domains (1) summary
      pfam08766
      Location:394 → 446
      DEK_C; DEK C terminal domain

    2. XM_005158227.5 → XP_005158284.1  protein DEK isoform X1

      See identical proteins and their annotated locations for XP_005158284.1

      UniProtKB/TrEMBL
      A0A8M3AID6
      Conserved Domains (1) summary
      pfam08766
      Location:394 → 446
      DEK_C; DEK C terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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