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    tfam transcription factor A, mitochondrial [ Danio rerio (zebrafish) ]

    Gene ID: 571106, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tfamprovided by ZNC
    Official Full Name
    transcription factor A, mitochondrialprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061013-552
    See related
    Ensembl:ENSDARG00000063145 AllianceGenome:ZFIN:ZDB-GENE-061013-552
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153358
    Summary
    Predicted to enable transcription cis-regulatory region binding activity. Acts upstream of or within regulation of female gonad development and regulation of mitochondrial DNA metabolic process. Predicted to be located in mitochondrial nucleoid and nucleus. Is expressed in several structures, including digestive system; gonad; muscle; pericardial region; and somite. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Orthologous to human TFAM (transcription factor A, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tfam in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (7254112..7263958)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (7220609..7230455)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate multikinase b Neighboring gene ubiquitin-conjugating enzyme E2D 1b Neighboring gene zgc:171971 Neighboring gene zgc:110716

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Persistence and Transcription of Paternal mtDNA Dependent on the Delivery Strategy Rather than Mitochondria Source in Fish Embryos. Peng L, et al. Cell Physiol Biochem, 2018. PMID 29961067
    2. Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos. Otten ABC, et al. Front Cell Dev Biol, 2020. PMID 32596237, Free PMC Article
    3. Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish model: Therapeutic implications for Parkinson's disease. Pinho BR, et al. Pharmacol Res, 2016 Jan. PMID 26657418
    4. A recessive variant in TFAM causes mtDNA depletion associated with primary ovarian insufficiency, seizures, intellectual disability and hearing loss. Ullah F, et al. Hum Genet, 2021 Dec. PMID 34647195
    5. The defective expression of gtpbp3 related to tRNA modification alters the mitochondrial function and development of zebrafish. Chen D, et al. Int J Biochem Cell Biol, 2016 Aug. PMID 27184967

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC153358

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding, bending IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of female gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mitochondrial DNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at mitochondrial promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor A, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077389.1 → NP_001070857.1  transcription factor A, mitochondrial

      See identical proteins and their annotated locations for NP_001070857.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124667
      UniProtKB/TrEMBL
      Q08BL2
      Related
      ENSDARP00000086442.4, ENSDART00000092009.6
      Conserved Domains (2) summary
      cd01390
      Location:152 → 213
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam00505
      Location:47 → 114
      HMG_box; HMG (high mobility group) box

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      7254112..7263958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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