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    samsn1a SAM domain, SH3 domain and nuclear localisation signals 1a [ Danio rerio (zebrafish) ]

    Gene ID: 336695, updated on 9-Dec-2024

    Summary

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    Official Symbol
    samsn1aprovided by ZNC
    Official Full Name
    SAM domain, SH3 domain and nuclear localisation signals 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8639
    See related
    Ensembl:ENSDARG00000054543 AllianceGenome:ZFIN:ZDB-GENE-030131-8639
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    samsn1; wu:fa92h05; wu:fq83f12
    Summary
    Predicted to be involved in negative regulation of B cell activation and regulation of intracellular signal transduction. Is expressed in blood; macrophage; and solid lens vesicle. Orthologous to human SAMSN1 (SAM domain, SH3 domain and nuclear localization signals 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See samsn1a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (29564374..29586699, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (29631495..29656195, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487762 Neighboring gene heat shock protein 70 family, member 13 Neighboring gene si:ch211-207n23.2 Neighboring gene uncharacterized LOC101886539

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Global analysis of hematopoietic and vascular endothelial gene expression by tissue specific microarray profiling in zebrafish. Covassin L, et al. Dev Biol, 2006 Nov 15. PMID 16999953, Free PMC Article
    2. Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Chestnut B, et al. Dev Dyn, 2020 Feb. PMID 31705559, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in negative regulation of B cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SAM domain-containing protein SAMSN-1a
    Names
    SAM domain, SH3 domain and nuclear localisation signals, 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128669.1 → NP_001122141.1  SAM domain-containing protein SAMSN-1a

      See identical proteins and their annotated locations for NP_001122141.1

      Status: PROVISIONAL

      Source sequence(s)
      BC162609
      UniProtKB/TrEMBL
      A0A8M1NHP4, B3DH22
      Related
      ENSDARP00000071220.4, ENSDART00000076749.7
      Conserved Domains (4) summary
      smart00454
      Location:540 → 584
      SAM; Sterile alpha motif
      cd11822
      Location:445 → 496
      SH3_SASH_like; Src homology 3 domain of SAM And SH3 Domain Containing Proteins
      pfam12485
      Location:307 → 442
      SLY; Lymphocyte signaling adaptor protein
      cl15755
      Location:521 → 584
      SAM_superfamily; SAM (Sterile alpha motif )

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      29564374..29586699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213480.1 → XP_068069581.1  SAM domain-containing protein SAMSN-1a isoform X4

      UniProtKB/TrEMBL
      A0A8M9QH42

    2. XM_068213479.1 → XP_068069580.1  SAM domain-containing protein SAMSN-1a isoform X3

    3. XM_021481348.2 → XP_021337023.1  SAM domain-containing protein SAMSN-1a isoform X2

      UniProtKB/TrEMBL
      A0A8M9QBV5
      Conserved Domains (3) summary
      cd11822
      Location:443 → 494
      SH3_SASH_like; Src homology 3 domain of SAM And SH3 Domain Containing Proteins
      pfam12485
      Location:307 → 440
      SLY; Lymphocyte signaling adaptor protein
      cl15755
      Location:519 → 582
      SAM_superfamily; SAM (Sterile alpha motif )

    4. XM_068213478.1 → XP_068069579.1  SAM domain-containing protein SAMSN-1a isoform X1

      UniProtKB/TrEMBL
      A0A8M1NHP4, B3DH22
    Nucleotide Protein Strain
    Heading Accession and Version

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