insb preproinsulin b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: insbprovided by ZNC
Official Full Name: preproinsulin bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040113-2
See related: Ensembl:ENSDARG00000034610 AllianceGenome:ZFIN:ZDB-GENE-040113-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable hormone activity. Predicted to be involved in glucose metabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blastomere; dermal bone; digestive system; kidney; and shield. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (28563083..28568162, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (28257125..28260367, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Temporal and spatial expression of two insulin genes (insa and insab) during early developmental stages.
Title: Early developmental expression of two insulins in zebrafish (Danio rerio).

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: preproinsulin b

Names: preproinsulin 2; zfins2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039064.1 → NP_001034153.1 preproinsulin b precursor

See identical proteins and their annotated locations for NP_001034153.1

Status: PROVISIONAL

Source sequence(s)

DQ156497

UniProtKB/TrEMBL

A0A2R8Q8K7, A0A2R8QQX1, Q2QAJ9

Related

ENSDARP00000137730.1, ENSDART00000172547.2

Conserved Domains (1) summary

cd04367
Location:24 → 106

IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...