fus FUS RNA binding protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fusprovided by ZNC
Official Full Name: FUS RNA binding proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1010
See related: Ensembl:ENSDARG00000037968 AllianceGenome:ZFIN:ZDB-GENE-040426-1010
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56390
Summary: Predicted to enable RNA binding activity and transcription coregulator activity. Acts upstream of or within axon extension. Predicted to be active in nucleus. Is expressed in gut; head; muscle; nervous system; and trunk. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Orthologous to human FUS (FUS RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (32698473..32711280)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (32566759..32579566)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish CCNF and FUS Mediate Stress-Specific Motor Responses.
Title: Zebrafish CCNF and FUS Mediate Stress-Specific Motor Responses.
Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations.
Title: Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations.
Data indicate a method for site-directed single nucleotide editing in two disease-related genes, DNA binding protein tardbp and RNA binding protein fus.
Title: Homology Directed Knockin of Point Mutations in the Zebrafish tardbp and fus Genes in ALS Using the CRISPR/Cas9 System.
TARDBP and FUS act in a pathogenic pathway that is independent of SOD1.
Title: FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA-binding protein FUS

Names: fusion (involved in t(12;16) in malignant liposarcoma)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201083.2 → NP_957377.2 RNA-binding protein FUS

Status: PROVISIONAL

Source sequence(s)

BX571714

UniProtKB/TrEMBL

A0A8M1PFK2, F1R0M4

Related

ENSDARP00000055339.5, ENSDART00000055340.7

Conserved Domains (4) summary

COG0724
Location:274 → 388

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12535
Location:297 → 382

RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins

sd00025
Location:446 → 467

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam00641
Location:443 → 472

zf-RanBP; Zn-finger in Ran binding protein and others