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    elf2a E74-like factor 2a (ets domain transcription factor) [ Danio rerio (zebrafish) ]

    Gene ID: 445489, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elf2aprovided by ZNC
    Official Full Name
    E74-like factor 2a (ets domain transcription factor)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040822-41
    See related
    Ensembl:ENSDARG00000019459 AllianceGenome:ZFIN:ZDB-GENE-040822-41
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj65e10; zgc:91894; wu:fj65e10
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in telencephalon. Orthologous to human ELF2 (E74 like ETS transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See elf2a in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (46047760..46070802, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (47060466..47083519, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene C1q and TNF related 2 Neighboring gene nocturnin a Neighboring gene mitochondria localized glutamic acid rich protein a Neighboring gene NADH:ubiquinone oxidoreductase subunit C1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genome-wide analysis of the zebrafish ETS family identifies three genes required for hemangioblast differentiation or angiogenesis. Liu F, et al. Circ Res, 2008 Nov 7. PMID 18832752
    2. ETS factors regulate Vegf-dependent arterial specification. Wythe JD, et al. Dev Cell, 2013 Jul 15. PMID 23830865, Free PMC Article
    3. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ETS-related transcription factor Elf-2a
    Names
    elf2l1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004116.1 → NP_001004116.1  ETS-related transcription factor Elf-2a

      See identical proteins and their annotated locations for NP_001004116.1

      Status: PROVISIONAL

      Source sequence(s)
      BC080260
      UniProtKB/TrEMBL
      A0A8M1N209, Q68EH3
      Related
      ENSDARP00000036411.4, ENSDART00000038670.6
      Conserved Domains (2) summary
      pfam00178
      Location:192 → 271
      Ets; Ets-domain
      pfam12310
      Location:4 → 112
      Elf-1_N; Transcription factor protein N terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      46047760..46070802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169610.5 → XP_005169667.1  ETS-related transcription factor Elf-2a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHF9
      Conserved Domains (2) summary
      pfam00178
      Location:191 → 270
      Ets; Ets-domain
      pfam12310
      Location:4 → 112
      Elf-1_N; Transcription factor protein N terminal

    2. XM_009291253.4 → XP_009289528.1  ETS-related transcription factor Elf-2a isoform X2

      UniProtKB/TrEMBL
      A0A8M3AGV9
      Conserved Domains (2) summary
      pfam00178
      Location:102 → 181
      Ets; Ets-domain
      pfam12310
      Location:7 → 22
      Elf-1_N; Transcription factor protein N terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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