mmp17b matrix metallopeptidase 17b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mmp17bprovided by ZNC
Official Full Name: matrix metallopeptidase 17bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-081107-17
See related: Ensembl:ENSDARG00000102956 AllianceGenome:ZFIN:ZDB-GENE-081107-17
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mmpl2; sb:eu434; si:ch211-199b20.1
Summary: Predicted to enable metalloendopeptidase activity. Acts upstream of or within neural crest cell migration. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Is expressed in artery; neural tube; spinal cord; trunk; and vein. Orthologous to human MMP17 (matrix metallopeptidase 17). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (48812500..48843234)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (49824777..49855340)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mmp17b is essential for proper neural crest cell migration in vivo.
Title: Mmp17b is essential for proper neural crest cell migration in vivo.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: matrix metalloproteinase-17b

Names: MMPLd; matrix metallopeptidase like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001365502.1 → NP_001352431.1 matrix metalloproteinase-17b isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL935334

UniProtKB/TrEMBL

A0A0R4IB00, A0A8M1RRF6

Related

ENSDARP00000131853.1, ENSDART00000161454.2

Conserved Domains (3) summary

cd00094
Location:350 → 540

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:145 → 308

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam01471
Location:55 → 108

PG_binding_1; Putative peptidoglycan binding domain
NM_001365503.1 → NP_001352432.1 matrix metalloproteinase-17b isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL935334

UniProtKB/TrEMBL

A0A8M9PZY9

Related

ENSDARP00000141607.1, ENSDART00000159976.2

Conserved Domains (3) summary

cd04278
Location:145 → 308

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam01471
Location:55 → 108

PG_binding_1; Putative peptidoglycan binding domain

cl02471
Location:350 → 447

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...