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    nmbb neuromedin Bb [ Danio rerio (zebrafish) ]

    Gene ID: 569893, updated on 9-Dec-2024

    Summary

    Official Symbol
    nmbbprovided by ZNC
    Official Full Name
    neuromedin Bbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081022-31
    See related
    Ensembl:ENSDARG00000077167 AllianceGenome:ZFIN:ZDB-GENE-081022-31
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:193683; zgc:193702
    Summary
    Predicted to enable neuromedin B receptor binding activity and neuropeptide hormone activity. Predicted to be involved in positive regulation of hormone secretion. Predicted to act upstream of or within neuropeptide signaling pathway. Predicted to be located in extracellular region and membrane. Predicted to be active in neuron projection. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NMB (neuromedin B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See nmbb in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (30085274..30087042, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (29814124..29815892, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene proline-serine-threonine phosphatase interacting protein 1b Neighboring gene tetraspanin 3b Neighboring gene alpha-kinase 3b Neighboring gene FERM domain containing 5b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables neuromedin B receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of hormone secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128756.1NP_001122228.1  neuromedin Bb

      See identical proteins and their annotated locations for NP_001122228.1

      Status: PROVISIONAL

      Source sequence(s)
      BC162178
      UniProtKB/TrEMBL
      A0A2R8Q6Q4, B3DFU2, F6NXI1
      Related
      ENSDARP00000097995.1, ENSDART00000112743.4
      Conserved Domains (1) summary
      pfam02044
      Location:5164
      Bombesin; Bombesin-like peptide

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      30085274..30087042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394696.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      53243..55011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)