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    mhc1laa major histocompatibility complex class I LAA [ Danio rerio (zebrafish) ]

    Gene ID: 550603, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mhc1laaprovided by ZNC
    Official Full Name
    major histocompatibility complex class I LAAprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-464
    See related
    Ensembl:ENSDARG00000016056 AllianceGenome:ZFIN:ZDB-GENE-050417-464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:113060; CH73-211L2.2
    Summary
    Predicted to be involved in immune response. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in prostate carcinoma and pulmonary tuberculosis. Orthologous to several human genes including CD1A (CD1a molecule); CD1B (CD1b molecule); and CD1C (CD1c molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mhc1laa in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (44442258..44450240)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (44448309..44456628)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:ch73-211l2.1 Neighboring gene major histocompatibility complex class I-related gene protein-like Neighboring gene major histocompatibility complex class I LBA Neighboring gene major histocompatibility complex class II d8.46a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of novel zebrafish MHC class I U lineage genes and their haplotype. Honjo Y, et al. Dev Comp Immunol, 2021 Mar. PMID 33279476
    2. Characterization of the Z lineage Major histocompatability complex class I genes in zebrafish. Dirscherl H, et al. Immunogenetics, 2014 Mar. PMID 24287892, Free PMC Article
    3. Multiple divergent haplotypes express completely distinct sets of class I MHC genes in zebrafish. McConnell SC, et al. Immunogenetics, 2014 Mar. PMID 24291825, Free PMC Article
    4. A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant. Dirscherl H, et al. Immunogenetics, 2015 Sep. PMID 26254596, Free PMC Article
    5. The MHC class I genes of zebrafish. Dirscherl H, et al. Dev Comp Immunol, 2014 Sep. PMID 24631581, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    major histocompatibility complex class I LAA

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017904.2 → NP_001017904.2  major histocompatibility complex class I LAA

      Status: VALIDATED

      Source sequence(s)
      CU571323
      UniProtKB/TrEMBL
      Q566P2
      Related
      ENSDARP00000123111.1, ENSDART00000143807.2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      44442258..44450240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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