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    ppih peptidylprolyl isomerase H (cyclophilin H) [ Danio rerio (zebrafish) ]

    Gene ID: 494165, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppihprovided by ZNC
    Official Full Name
    peptidylprolyl isomerase H (cyclophilin H)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040625-127
    See related
    Ensembl:ENSDARG00000041530 AllianceGenome:ZFIN:ZDB-GENE-040625-127
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55766; zgc:86780; zgc:136730; zgc:158595
    Summary
    Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Acts upstream of or within angiogenesis. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human PPIH (peptidylprolyl isomerase H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ppih in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (47152704..47206399, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (47162238..47215933, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene espin Neighboring gene espin-like protein Neighboring gene Rho guanine nucleotide exchange factor (GEF) 16 Neighboring gene si:dkeyp-100a1.6 Neighboring gene Y box binding protein 1 Neighboring gene uncharacterized LOC101883933 Neighboring gene methylenetetrahydrofolate reductase (NAD(P)H)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Taste receptors and gustatory associated G proteins in channel catfish, Ictalurus punctatus. Gao S, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2017 Mar. PMID 27806254
    2. Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets. Kalén M, et al. Chem Biol, 2009 Apr 24. PMID 19389629, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC55766, MGC136730, MGC158595

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase H
    NP_001009902.2
    NP_957499.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009902.2 → NP_001009902.2  peptidyl-prolyl cis-trans isomerase H isoform 1

      See identical proteins and their annotated locations for NP_001009902.2

      Status: PROVISIONAL

      Source sequence(s)
      BC114258
      UniProtKB/TrEMBL
      A0A8N7XJI6, F1R6Z6, F6PF84, Q6TLD7
      Related
      ENSDARP00000060876.3, ENSDART00000060877.5
      Conserved Domains (1) summary
      cl00197
      Location:2 → 177
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

    2. NM_201205.1 → NP_957499.1  peptidyl-prolyl cis-trans isomerase H isoform 2

      See identical proteins and their annotated locations for NP_957499.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045448
      UniProtKB/TrEMBL
      A0A8M1PFU0, Q7ZVQ9
      Related
      ENSDARP00000060882.4, ENSDART00000060883.6
      Conserved Domains (1) summary
      cd01926
      Location:11 → 175
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      47152704..47206399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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