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    macf1a microtubule actin crosslinking factor 1a [ Danio rerio (zebrafish) ]

    Gene ID: 562190, updated on 9-Dec-2024

    Summary

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    Official Symbol
    macf1aprovided by ZNC
    Official Full Name
    microtubule actin crosslinking factor 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3606
    See related
    Ensembl:ENSDARG00000028533 AllianceGenome:ZFIN:ZDB-GENE-030131-3606
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    macf1; fc46g01; wu:fc46g01; si:rp71-45k5.7
    Summary
    Predicted to enable structural molecule activity. Involved in organelle disassembly. Acts upstream of or within oocyte animal/vegetal axis specification. Is active in cell cortex and mitochondrial cloud. Is expressed in hair cell anterior macula; inner ear; macula; oocyte stage I; and posterior crista. Human ortholog(s) of this gene implicated in lissencephaly 9 with complex brainstem malformation. Orthologous to human MACF1 (microtubule actin crosslinking factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See macf1a in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    107
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (35039957..35351108, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (35452837..35763994, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene zgc:91910 Neighboring gene bone morphogenetic protein 8a Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 Neighboring gene ring finger protein 19B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Widespread Separation of the Polypyrimidine Tract From 3' AG by G Tracts in Association With Alternative Exons in Metazoa and Plants. Nguyen H, et al. Front Genet, 2018. PMID 30693020, Free PMC Article
    2. Efficient mutation identification in zebrafish by microarray capturing and next generation sequencing. Bontems F, et al. Biochem Biophys Res Commun, 2011 Feb 18. PMID 21219859
    3. Microtubule-actin crosslinking factor 1 (Macf1) domain function in Balbiani body dissociation and nuclear positioning. Escobar-Aguirre M, et al. PLoS Genet, 2017 Sep. PMID 28880872, Free PMC Article
    4. Microtubule actin crosslinking factor 1 regulates the Balbiani body and animal-vegetal polarity of the zebrafish oocyte. Gupta T, et al. PLoS Genet, 2010 Aug 19. PMID 20808893, Free PMC Article
    5. ACF7 is a hair-bundle antecedent, positioned to integrate cuticular plate actin and somatic tubulin. Antonellis PJ, et al. J Neurosci, 2014 Jan 1. PMID 24381291, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We propose that Macf1a does not function via its canonical mechanism of linking two cytoskeletal systems together in dissociating the Bb. Instead our results suggest that Macf1a functions by linking one cytoskeletal system, cortical actin, to another structure, the Bb, where Macf1a is localized.
      Title: Microtubule-actin crosslinking factor 1 (Macf1) domain function in Balbiani body dissociation and nuclear positioning.
    2. Macf1 regulates the balbiani body and the polarity of oocyte.
      Title: Microtubule actin crosslinking factor 1 regulates the Balbiani body and animal-vegetal polarity of the zebrafish oocyte.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intermediate filament cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within oocyte animal/vegetal axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organelle disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial cloud IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-actin cross-linking factor 1
    Names
    acf7a
    magellan
    mgn
    microfilament and actin filament cross-linker protein
    microtubule-actin crosslinking factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      35039957..35351108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215319.1 → XP_068071420.1  microtubule-actin cross-linking factor 1 isoform X21

      UniProtKB/TrEMBL
      A0A8M3AL27

    2. XM_068215321.1 → XP_068071422.1  microtubule-actin cross-linking factor 1 isoform X23

      UniProtKB/TrEMBL
      A0A8M3AL27

    3. XM_068215322.1 → XP_068071423.1  microtubule-actin cross-linking factor 1 isoform X25

      UniProtKB/TrEMBL
      A0A8M3AVP3

    4. XM_009294348.4 → XP_009292623.1  microtubule-actin cross-linking factor 1 isoform X24

      UniProtKB/TrEMBL
      A0A8M3ASP9, A0A8M3AVP3
      Conserved Domains (8) summary
      smart00243
      Location:7747 → 7825
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:7520 → 7638
      SPEC; Spectrin repeats
      cd00014
      Location:80 → 182
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00051
      Location:7672 → 7734
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:7298 → 7510
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:1763 → 1802
      Plectin; Plectin repeat
      pfam13499
      Location:7673 → 7733
      EF-hand_7; EF-hand domain pair
      cl02488
      Location:1182 → 1341
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    5. XM_068215311.1 → XP_068071412.1  microtubule-actin cross-linking factor 1 isoform X13

      UniProtKB/TrEMBL
      A0A8M6YU02

    6. XM_068215320.1 → XP_068071421.1  microtubule-actin cross-linking factor 1 isoform X22

      UniProtKB/TrEMBL
      A0A8M6YWG4

    7. XM_068215318.1 → XP_068071419.1  microtubule-actin cross-linking factor 1 isoform X20

      UniProtKB/TrEMBL
      A0A8M6YWG4

    8. XM_068215310.1 → XP_068071411.1  microtubule-actin cross-linking factor 1 isoform X12

      UniProtKB/TrEMBL
      A0A8M6YWG4

    9. XM_068215317.1 → XP_068071418.1  microtubule-actin cross-linking factor 1 isoform X19

      UniProtKB/TrEMBL
      A0A8M6Z331
      Related
      ENSDARP00000054273.6, ENSDART00000054274.6

    10. XM_068215316.1 → XP_068071417.1  microtubule-actin cross-linking factor 1 isoform X18

      UniProtKB/TrEMBL
      A0A8M6Z2G6

    11. XM_068215313.1 → XP_068071414.1  microtubule-actin cross-linking factor 1 isoform X15

      UniProtKB/TrEMBL
      A0A8M6Z2G6

    12. XM_068215315.1 → XP_068071416.1  microtubule-actin cross-linking factor 1 isoform X17

      UniProtKB/TrEMBL
      A0A8M6YWG9

    13. XM_068215312.1 → XP_068071413.1  microtubule-actin cross-linking factor 1 isoform X14

      UniProtKB/TrEMBL
      A0A8M6YWG9

    14. XM_068215314.1 → XP_068071415.1  microtubule-actin cross-linking factor 1 isoform X16

      UniProtKB/TrEMBL
      A0A8M6YUL9

    15. XM_068215303.1 → XP_068071404.1  microtubule-actin cross-linking factor 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M9P1Z8

    16. XM_068215309.1 → XP_068071410.1  microtubule-actin cross-linking factor 1 isoform X11

      UniProtKB/TrEMBL
      A0A8M6YUL3

    17. XM_068215308.1 → XP_068071409.1  microtubule-actin cross-linking factor 1 isoform X10

      UniProtKB/TrEMBL
      A0A8M3AKC0

    18. XM_068215306.1 → XP_068071407.1  microtubule-actin cross-linking factor 1 isoform X8

      UniProtKB/TrEMBL
      A0A8M3ASP2

    19. XM_068215300.1 → XP_068071401.1  microtubule-actin cross-linking factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M6YTZ6

    20. XM_068215307.1 → XP_068071408.1  microtubule-actin cross-linking factor 1 isoform X9

      UniProtKB/TrEMBL
      A0A8M3AKC0

    21. XM_068215304.1 → XP_068071405.1  microtubule-actin cross-linking factor 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M3AVN6

    22. XM_068215302.1 → XP_068071403.1  microtubule-actin cross-linking factor 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M3AL24

    23. XM_068215301.1 → XP_068071402.1  microtubule-actin cross-linking factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B696

    24. XM_068215305.1 → XP_068071406.1  microtubule-actin cross-linking factor 1 isoform X7

      UniProtKB/TrEMBL
      A0A8M6Z2F9

    25. XM_068215299.1 → XP_068071400.1  microtubule-actin cross-linking factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z318
    Nucleotide Protein Strain
    Heading Accession and Version

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