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    pot1 protection of telomeres 1 homolog [ Danio rerio (zebrafish) ]

    Gene ID: 566847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pot1provided by ZNC
    Official Full Name
    protection of telomeres 1 homologprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-110324-1
    See related
    Ensembl:ENSDARG00000079915 AllianceGenome:ZFIN:ZDB-GENE-110324-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable G-rich strand telomeric DNA binding activity and telomerase inhibitor activity. Predicted to be involved in regulation of telomere maintenance via telomerase and telomere capping. Predicted to act upstream of or within telomere maintenance. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of nuclear telomere cap complex. Is expressed in several structures, including blastomere; digestive system; gill; heart; and ovary. Human ortholog(s) of this gene implicated in colorectal cancer; familial melanoma; hepatocellular carcinoma; lung cancer; and ovarian cancer. Orthologous to human POT1 (protection of telomeres 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pot1 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (27405793..27491914)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (26962574..27048715)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489402 Neighboring gene uncharacterized LOC103909868 Neighboring gene G protein-coupled receptor 37a Neighboring gene sperm adhesion molecule 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish as a model system to study the physiological function of telomeric protein TPP1. Xie Y, et al. PLoS One, 2011 Feb 2. PMID 21311760, Free PMC Article
    2. The knockdown efficiency of telomere associated genes with specific methodology in a zebrafish cell line. Hu X, et al. Biochimie, 2021 Nov. PMID 34214617
    3. Knockout of Shelterin subunit genes in zebrafish results in distinct outcomes. Ma J, et al. Biochem Biophys Res Commun, 2022 Aug 20. PMID 35667242
    4. The differential spatiotemporal expression pattern of shelterin genes throughout lifespan. Wagner KD, et al. Aging (Albany NY), 2017 Apr. PMID 28437249, Free PMC Article
    5. The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging. Ying Y, et al. Nucleic Acids Res, 2022 Feb 28. PMID 35150283, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-rich strand telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables telomerase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear telomere cap complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protection of telomeres protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001245960.1 → NP_001232889.1  protection of telomeres protein 1

      See identical proteins and their annotated locations for NP_001232889.1

      Status: PROVISIONAL

      Source sequence(s)
      HQ652076
      UniProtKB/TrEMBL
      F1D6H6
      Related
      ENSDARP00000129477.1, ENSDART00000154362.2
      Conserved Domains (2) summary
      cd04497
      Location:151 → 283
      hPOT1_OB1_like; hPOT1_OB1_like: A subfamily of OB folds similar to the first OB fold (OB1) of human protection of telomeres 1 protein (hPOT1), the single OB fold of the N-terminal domain of Schizosaccharomyces pombe POT1 (SpPOT1), and the first OB fold of the N-terminal ...
      pfam16686
      Location:295 → 438
      POT1PC; ssDNA-binding domain of telomere protection protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      27405793..27491914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163119.5 → XP_005163176.1  protection of telomeres protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BA64, E7F0D5
      Related
      ENSDARP00000102969.2, ENSDART00000115139.5
      Conserved Domains (2) summary
      cd04497
      Location:151 → 283
      hPOT1_OB1_like; hPOT1_OB1_like: A subfamily of OB folds similar to the first OB fold (OB1) of human protection of telomeres 1 protein (hPOT1), the single OB fold of the N-terminal domain of Schizosaccharomyces pombe POT1 (SpPOT1), and the first OB fold of the N-terminal ...
      pfam16686
      Location:295 → 438
      POT1PC; ssDNA-binding domain of telomere protection protein

    2. XM_021470509.2 → XP_021326184.1  protection of telomeres protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PMS4
      Related
      ENSDARP00000145879.1, ENSDART00000183266.1
      Conserved Domains (2) summary
      cd04497
      Location:151 → 283
      hPOT1_OB1_like; A subfamily of OB folds similar to the first OB fold (OB1) of human protection of telomeres 1 protein (hPOT1), the single OB fold of the N-terminal domain of Schizosaccharomyces pombe POT1 (SpPOT1), and the first OB fold of the N-terminal domain of the ...
      pfam16686
      Location:295 → 438
      POT1PC; ssDNA-binding domain of telomere protection protein

    3. XM_068217400.1 → XP_068073501.1  protection of telomeres protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PUZ9

    4. XM_021470510.2 → XP_021326185.1  protection of telomeres protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PYF2
      Conserved Domains (2) summary
      cd04497
      Location:151 → 283
      hPOT1_OB1_like; A subfamily of OB folds similar to the first OB fold (OB1) of human protection of telomeres 1 protein (hPOT1), the single OB fold of the N-terminal domain of Schizosaccharomyces pombe POT1 (SpPOT1), and the first OB fold of the N-terminal domain of the ...
      pfam16686
      Location:295 → 438
      POT1PC; ssDNA-binding domain of telomere protection protein

    5. XM_068217399.1 → XP_068073500.1  protection of telomeres protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BA64, E7F0D5
    Nucleotide Protein
    Heading Accession and Version

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