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    rxfp2a relaxin family peptide receptor 2a [ Danio rerio (zebrafish) ]

    Gene ID: 792884, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rxfp2aprovided by ZNC
    Official Full Name
    relaxin family peptide receptor 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1225
    See related
    Ensembl:ENSDARG00000032820 AllianceGenome:ZFIN:ZDB-GENE-040426-1225
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rxfp2; lgr8.1; rxfp2b; zgc:63668
    Summary
    Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and hormone-mediated signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in female organism; male organism; ovary; and testis. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human RXFP2 (relaxin family peptide receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: This record was renamed from rxfp2b to rxfp2a based on PMID:22470432. [11/17/2015] [17 Nov 2015]
    Orthologs
    all
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    Genomic context

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    See rxfp2a in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (33754608..33867766)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (33811107..33923881)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene beta 3-glucosyltransferase b Neighboring gene uncharacterized LOC101886689 Neighboring gene DNA ligase 1-like Neighboring gene furry homolog b (Drosophila) Neighboring gene uncharacterized LOC103911763 Neighboring gene zygote arrest 1-like Neighboring gene klotho

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Using paleogenomics to study the evolution of gene families: origin and duplication history of the relaxin family hormones and their receptors. Yegorov S, et al. PLoS One, 2012. PMID 22470432, Free PMC Article
    2. Expression pattern of zebrafish rxfp2 homologue genes during embryonic development. Donizetti A, et al. J Exp Zool B Mol Dev Evol, 2015 Nov. PMID 26173401
    3. Japanese medaka as a model for studying the relaxin family genes involved in neuroendocrine regulation: Insights from the expression of fish-specific rln3 and insl5 and rxfp3/4-type receptor paralogues. Alnafea H, et al. Mol Cell Endocrinol, 2019 May 1. PMID 30703485
    4. Estrogen-induced inhibition of spermatogenesis in zebrafish is largely reversed by androgen. de Castro Assis LH, et al. J Mol Endocrinol, 2018 May. PMID 29476039
    5. New insights into ligand-receptor pairing and coevolution of relaxin family peptides and their receptors in teleosts. Good S, et al. Int J Evol Biol, 2012. PMID 23008798, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analyzed the expression pattern of three rxfp2 homologue genes in zebrafish embryonic development
      Title: Expression pattern of zebrafish rxfp2 homologue genes during embryonic development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63668

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    relaxin receptor 2a
    Names
    relaxin/insulin-like family peptide receptor 2
    relaxin/insulin-like family peptide receptor 2a
    relaxin/insulin-like family peptide receptor 2b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328384.1 → NP_001315313.1  relaxin receptor 2a

      Status: VALIDATED

      Source sequence(s)
      BX569785, CR555290
      UniProtKB/TrEMBL
      A0A0R3P9B9, A0A8M1PA79
      Related
      ENSDARP00000127216.1, ENSDART00000153442.3
      Conserved Domains (4) summary
      cd00112
      Location:42 → 77
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      sd00033
      Location:136 → 159
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:304 → 360
      LRR_8; Leucine rich repeat
      cl21561
      Location:422 → 647
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      33754608..33867766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223827.1 → XP_068079928.1  relaxin receptor 2a isoform X1

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394793.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      183480..301348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395291.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      183936..242931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_200443.1: Suppressed sequence

      Description
      NM_200443.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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