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    iqgap1 IQ motif containing GTPase activating protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 100002928, updated on 9-Dec-2024

    Summary

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    Official Symbol
    iqgap1provided by ZNC
    Official Full Name
    IQ motif containing GTPase activating protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050809-24
    See related
    Ensembl:ENSDARG00000078888 AllianceGenome:ZFIN:ZDB-GENE-050809-24
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7152854; im:7156663
    Summary
    Predicted to enable GTPase activator activity; actin filament binding activity; and calmodulin binding activity. Predicted to be involved in epidermal growth factor receptor signaling pathway; fibroblast migration; and mitotic actomyosin contractile ring assembly actin filament organization. Predicted to be located in plasma membrane bounded cell projection. Predicted to be active in cell cortex and nucleus. Is expressed in several structures, including cardiovascular system; ectoderm; gut; perichondrium; and pharyngeal arch. Orthologous to human IQGAP1 (IQ motif containing GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See iqgap1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (50644424..50764507, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (50371642..50489211, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496214 Neighboring gene ADAMTS like 5 Neighboring gene CREB regulated transcription coactivator 3 Neighboring gene uncharacterized LOC137496215 Neighboring gene cocaine- and amphetamine-regulated transcript-like Neighboring gene uncharacterized LOC137496216 Neighboring gene death domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Determination of dissociation constants in living zebrafish embryos with single wavelength fluorescence cross-correlation spectroscopy. Shi X, et al. Biophys J, 2009 Jul 22. PMID 19619483, Free PMC Article
    2. IQGAP3 is essential for cell proliferation and motility during zebrafish embryonic development. Fang X, et al. Cytoskeleton (Hoboken), 2015 Aug. PMID 26286209, Free PMC Article
    3. A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth. Mayrhofer M, et al. Dis Model Mech, 2017 Jan 1. PMID 27935819, Free PMC Article
    4. Dynamics of zebrafish fin regeneration using a pulsed SILAC approach. Nolte H, et al. Proteomics, 2015 Feb. PMID 25504979
    5. Many genes in fish have species-specific asymmetric rates of molecular evolution. Steinke D, et al. BMC Genomics, 2006 Feb 8. PMID 16466575, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fibroblast migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic actomyosin contractile ring assembly actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane bounded cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras GTPase-activating-like protein IQGAP1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308966.1 → NP_001295895.1  ras GTPase-activating-like protein IQGAP1

      See identical proteins and their annotated locations for NP_001295895.1

      Status: PROVISIONAL

      Source sequence(s)
      KP862587
      UniProtKB/TrEMBL
      A0A0F7C9F3
      Related
      ENSDARP00000098704.2, ENSDART00000110283.5
      Conserved Domains (6) summary
      smart00015
      Location:774 → 794
      IQ; Calmodulin-binding motif
      smart00323
      Location:991 → 1343
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:43 → 157
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00201
      Location:682 → 711
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam03836
      Location:1453 → 1578
      RasGAP_C; RasGAP C-terminus
      cl02569
      Location:1002 → 1381
      RasGAP; Ras GTPase Activating Domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      50644424..50764507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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