U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    gsdf gonadal somatic cell derived factor [ Danio rerio (zebrafish) ]

    Gene ID: 571289, updated on 15-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    gsdfprovided by ZNC
    Official Full Name
    gonadal somatic cell derived factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-101029-3
    See related
    Ensembl:ENSDARG00000075301 AllianceGenome:ZFIN:ZDB-GENE-101029-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable growth factor activity. Acts upstream of or within oocyte maturation. Predicted to be located in extracellular region. Is expressed in granulosa cell and reproductive system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See gsdf in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (198260..205218)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (11830..20561)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene kelch-like family member 8 Neighboring gene AF4/FMR2 family, member 1 Neighboring gene protein phosphatase with EF-hand domain 2b Neighboring gene serine/threonine-protein phosphatase with EF-hands 2 Neighboring gene nucleoporin 54

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The proximal promoter region of the zebrafish gsdf gene is sufficient to mimic the spatio-temporal expression pattern of the endogenous gene in Sertoli and granulosa cells. Gautier A, et al. Biol Reprod, 2011 Dec. PMID 21816849
    2. Establishment of transgenic zebrafish (Danio rerio) models expressing fluorescence proteins in the oocytes and somatic supporting cells. Song Y, et al. Gen Comp Endocrinol, 2021 Dec 1. PMID 34543655
    3. GFP expression pattern in pituitary and gonads under the control of nuclear progesterone receptor promoter in transgenic zebrafish. Huang J, et al. Dev Dyn, 2020 Nov. PMID 32506585
    4. Application of dead end-knockout zebrafish as recipients of germ cell transplantation. Li Q, et al. Mol Reprod Dev, 2017 Oct. PMID 28731265
    5. Optimization of the Gal4/UAS transgenic tools in zebrafish. Zhang Y, et al. Appl Microbiol Biotechnol, 2019 Feb. PMID 30613898

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In zebrafish, gsdf regulates ovarian follicle maturation and expression of genes for steroid biosynthesis, obesity, diabetes, and female fertility, leading to ovarian and extra-ovarian phenotypes that mimic human polycystic ovarian syndrome (PCOS)
      Title: Gonadal soma controls ovarian follicle proliferation through Gsdf in zebrafish.
    2. evolutionarily conserved DNA motifs may be involved in Sertoli and granulosa cell-specific expression
      Title: The proximal promoter region of the zebrafish gsdf gene is sufficient to mimic the spatio-temporal expression pattern of the endogenous gene in Sertoli and granulosa cells.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    gonadal somatic cell derived factor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114668.1 → NP_001108140.1  gonadal somatic cell derived factor precursor

      See identical proteins and their annotated locations for NP_001108140.1

      Status: PROVISIONAL

      Source sequence(s)
      EU378916
      UniProtKB/TrEMBL
      A0A2R8QCF5, B0ZE98, G1CSU3
      Related
      ENSDARP00000149345.1, ENSDART00000193485.1
      Conserved Domains (1) summary
      cl02510
      Location:85 → 157
      TGF_beta; Transforming growth factor beta like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      198260..205218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173843.5 → XP_005173900.1  gonadal somatic cell derived factor isoform X2

      UniProtKB/TrEMBL
      A0A0R4IHC8, A0A8M2BLI7
      Related
      ENSDARP00000134025.2, ENSDART00000163696.2
      Conserved Domains (1) summary
      cl02510
      Location:84 → 156
      TGF_beta; Transforming growth factor beta like domain

    2. XM_003200793.6 → XP_003200841.1  gonadal somatic cell derived factor isoform X1

      UniProtKB/TrEMBL
      A0A8M1RP53
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools