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    mtpap mitochondrial poly(A) polymerase [ Danio rerio (zebrafish) ]

    Gene ID: 563801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mtpapprovided by ZNC
    Official Full Name
    mitochondrial poly(A) polymeraseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-101208-3
    See related
    Ensembl:ENSDARG00000076155 AllianceGenome:ZFIN:ZDB-GENE-101208-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in RNA 3'-end processing. Predicted to be active in mitochondrion. Is expressed in head; heart; ovary; and testis. Human ortholog(s) of this gene implicated in spastic ataxia 4. Orthologous to human MTPAP (mitochondrial poly(A) polymerase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mtpap in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (23664369..23674820)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (23543031..23555044)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911922 Neighboring gene mitogen-activated protein kinase kinase kinase 8 Neighboring gene junctional cadherin 5 associated a Neighboring gene supervillin a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Terminal Uridylyltransferases Execute Programmed Clearance of Maternal Transcriptome in Vertebrate Embryos. Chang H, et al. Mol Cell, 2018 Apr 5. PMID 29625039
    2. Hen1 is required for oocyte development and piRNA stability in zebrafish. Kamminga LM, et al. EMBO J, 2010 Nov 3. PMID 20859253, Free PMC Article
    3. Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency. Zhang Q, et al. Nucleic Acids Res, 2021 May 7. PMID 33836087, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    poly(A) RNA polymerase, mitochondrial
    Names
    TUTase 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      23664369..23674820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480322.2 → XP_021335997.2  poly(A) RNA polymerase, mitochondrial

      UniProtKB/TrEMBL
      A0A8M9PX24, E7FEW2
      Related
      ENSDARP00000100165.2, ENSDART00000111334.4

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394842.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      31750..42983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_687164.9 → XP_692256.6  poly(A) RNA polymerase, mitochondrial

      UniProtKB/TrEMBL
      A0A8M9PX24, E7FEW2
    Nucleotide Protein Strain
    Heading Accession and Version

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