st8sia7.1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 7.1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: st8sia7.1provided by ZNC
Official Full Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 7.1provided by ZNC
Primary source: ZFIN:ZDB-GENE-090504-4
See related: Ensembl:ENSDARG00000054211 AllianceGenome:ZFIN:ZDB-GENE-090504-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: siat 8G-r1
Summary: Predicted to enable alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Predicted to be involved in N-glycan processing; oligosaccharide metabolic process; and protein glycosylation. Predicted to act upstream of or within sphingolipid metabolic process. Predicted to be located in Golgi membrane. Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Orthologous to human ST8SIA6 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (44797665..44819143, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (45085613..45107078, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identified and characterized a new alpha2,8-sialyltransferase sequence in Danio rerio showing no transfer activity on sialylated fetuin. This sequence belongs to a new teleost mono-alpha2,8-sialyltransferase subfamily resulting from the second whole genome duplication event.
Title: Novel Zebrafish Mono-α2,8-sialyltransferase (ST8Sia VIII): An Evolutionary Perspective of α2,8-Sialylation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IEA Inferred from Electronic Annotation more info
enables sialyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-glycan processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in oligosaccharide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein glycosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 7.1

Names: ST8Sia VIIA; alpha 2,8-sialyltransferase ST8Sia I/V/VI-r1

NP_001373444.1

EC 2.4.3.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001386515.1 → NP_001373444.1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 7.1

Status: VALIDATED

Source sequence(s)

CU682777

UniProtKB/TrEMBL

A0A8M9PX36, F1QXR5

Related

ENSDARP00000070847.5, ENSDART00000076373.7

Conserved Domains (1) summary

pfam00777
Location:103 → 352

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)