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    tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 403084, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tab1provided by ZNC
    Official Full Name
    TGF-beta activated kinase 1/MAP3K7 binding protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060628-1
    See related
    Ensembl:ENSDARG00000036613 AllianceGenome:ZFIN:ZDB-GENE-060628-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    map3k7ip1
    Summary
    Predicted to enable kinase activity and protein serine/threonine phosphatase activity. Predicted to act upstream of or within neutrophil chemotaxis and non-canonical NF-kappaB signal transduction. Orthologous to human TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See tab1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (181133..185610)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (163082..167556)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495904 Neighboring gene LYL1 basic helix-loop-helix family member Neighboring gene GTPase IMAP family member 6 Neighboring gene beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase b Neighboring gene C1q and TNF related 6b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. TAK1-binding proteins (TAB1 and TAB2) in grass carp (Ctenopharyngodon idella): identification, characterization, and expression analysis after infection with Ichthyophthirius multifiliis. Zhao F, et al. Fish Shellfish Immunol, 2014 Jun. PMID 24747054
    2. MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation. Zhou W, et al. Cell Rep, 2018 Feb 13. PMID 29444433, Free PMC Article
    3. YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths. Lin J, et al. Natl Sci Rev, 2023 Dec. PMID 38152479, Free PMC Article
    4. Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. Coppola U, et al. BMC Evol Biol, 2016 Jan 27. PMID 26818140, Free PMC Article
    5. Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish. Stein C, et al. Genome Biol, 2007. PMID 18039395, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within neutrophil chemotaxis IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within non-canonical NF-kappaB signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
    Names
    TAK1-binding protein 1
    mitogen-activated protein kinase kinase kinase 7 interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      181133..185610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002662240.7 → XP_002662286.4  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

      UniProtKB/TrEMBL
      A0A8M1RLT6
      Related
      ENSDARP00000053182.6, ENSDART00000053183.6
      Conserved Domains (1) summary
      cd00143
      Location:26 → 327
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein Strain
    Heading Accession and Version

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