nup37 nucleoporin 37 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nup37provided by ZNC
Official Full Name: nucleoporin 37provided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-363
See related: Ensembl:ENSDARG00000094191 AllianceGenome:ZFIN:ZDB-GENE-040718-363
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92259
Summary: Acts upstream of or within heart development. Predicted to be part of nuclear pore outer ring. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NUP37 (nucleoporin 37). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (17327710..17370410)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (17338734..17381434)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of nuclear pore outer ring	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore outer ring	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleoporin Nup37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002619.1 → NP_001002619.1 nucleoporin Nup37

See identical proteins and their annotated locations for NP_001002619.1

Status: PROVISIONAL

Source sequence(s)

BC075968

UniProtKB/TrEMBL

Q6DHK2

Related

ENSDARP00000018434.6, ENSDART00000016075.8

Conserved Domains (3) summary

COG2319
Location:71 → 277

WD40; WD40 repeat [General function prediction only]

sd00039
Location:77 → 122

7WD40; WD40 repeat [structural motif]

cl02567
Location:30 → 237

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...